Li Jingbing, Mou Jing, Wang Yichen, Zhang Yiling, Mou Ping
Department of dermatology, Xuzhou Central Hospital, Xuzhou, China.
Cardiovascular Research Center, Xuzhou Central Hospital, Xuzhou, China.
Ann Transl Med. 2023 Feb 28;11(4):180. doi: 10.21037/atm-23-448.
Cutaneous sporotrichosis is prevalent worldwide and a common subcutaneous fungal disease in northeast China. The incidence of cutaneous sporotrichosis in southern China cannot be ignored. Previous studies have revealed differences between different regions in China regarding populations susceptible to infection, cause of infection, and pathological mechanisms of sporotrichosis. Therefore, This study aimed to analyze the differences in the epidemiological characteristics of cutaneous sporotrichosis in different regions of China to provide a reference for regional prevention, control, and treatment.
We searched PubMed, EMBASE, Cochrane Library, CNKI, WanFang Data, and VIP for published reports on cutaneous sporotrichosis in China. The information about the characteristics of populations getting cutaneous sporotrichosis, causes of infection, disease types, and treatment regimens was extracted from studies to construct a knowledge database of cutaneous sporotrichosis in China. Taking the Qinling Mountains-Huaihe River line as the boundary to divide China into the northern and southern, the epidemiological characteristics of cutaneous sporotrichosis in two parts of China were analyzed.
In northern China, more women than men get cutaneous sporotrichosis (60.4% 39.6%), while it is the other way around in southern China (men women: 50.6% 49.4%). In northern China, the incidence of this disease was more concentrated in spring (34.0%) and winter (35.7%), while in southern China, this disease frequently spread in spring (48.1%) and summer (26.9%). In the north, cutaneous sporotrichosis usually affected the face (50.1%) and limbs (45.3%), while in the south, it targets limbs (72.6%). In northern China, potassium iodide (30.5%) and combination therapy (37.8%) were preferred, while in southern China, potassium iodide (86.0%) was the main choice. Although there was a significant difference in treatment regimens (P<0.05), no significant difference emerged in cure rates between northern and southern China (98.5% 98.4%, P>0.05).
It is the first retrospective study on sporotrichosis in China. It describes the prevention of sporotrichosis in China since it was first reported and also reflects the differences in sporotrichosis between the northern and southern of China. This study provides a valuable reference for the prevention, control, and treatment of sporotrichosis in different regions of China.
皮肤孢子丝菌病在全球范围内普遍存在，是中国东北地区常见的皮下真菌病。中国南方皮肤孢子丝菌病的发病率也不容小觑。以往研究揭示了中国不同地区在孢子丝菌病的易感人群、感染原因及病理机制方面存在差异。因此，本研究旨在分析中国不同地区皮肤孢子丝菌病流行病学特征的差异，为区域预防、控制和治疗提供参考。
我们检索了PubMed、EMBASE、Cochrane图书馆、中国知网、万方数据和维普资讯，查找关于中国皮肤孢子丝菌病的已发表报告。从研究中提取有关患皮肤孢子丝菌病人群的特征、感染原因、疾病类型及治疗方案的信息，构建中国皮肤孢子丝菌病知识数据库。以秦岭 - 淮河线为界将中国分为南北两部分，分析中国两部分地区皮肤孢子丝菌病的流行病学特征。
在中国北方，患皮肤孢子丝菌病的女性多于男性（60.4%对39.6%），而在中国南方情况则相反（男性对女性：50.6%对49.4%）。在中国北方，该病发病率在春季（34.0%）和冬季（35.7%）更为集中，而在中国南方，该病常在春季（48.1%）和夏季（26.9%）频繁传播。在北方，皮肤孢子丝菌病通常累及面部（50.1%）和四肢（45.3%），而在南方，其主要累及四肢（72.6%）。在中国北方，碘化钾（30.5%）和联合治疗（37.8%）是首选治疗方法，而在中国南方，碘化钾（86.0%）是主要选择。尽管治疗方案存在显著差异（P<0.05），但中国南北地区的治愈率无显著差异（98.5%对98.4%，P>0.05）。
这是中国首次关于孢子丝菌病的回顾性研究。它描述了中国自首次报告孢子丝菌病以来的防治情况，也反映了中国南北地区孢子丝菌病的差异。本研究为中国不同地区孢子丝菌病的预防、控制和治疗提供了有价值的参考。
