Ye C C, Wu Y F
Department of Periodontology, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2022 Jun 9;57(6):635-641. doi: 10.3760/cma.j.cn112144-20220410-00166.
Oral microbiome dysbiosis, triggered by increased oral pathogens or decreased commercial bacteria, leads to oral and systemic diseases. Recent ecological events suggest that periodontal disease is a risk factor of adverse pregnancy outcomes. The oral microbiome dysbiosis is believed to be associated with oral disease and adverse pregnancy outcomes (APO). However, the pathogenic mechanisms have not yet been elucidated. In this review, we summarize the recent literature on how pregnancy associated pathogenic oral microbiome dysbiosis can trigger gestational periodontal diseases and poor birth outcomes, especially the role of periodontal pathogenic bacteria in the mechanisms of how gestational periodontal diseases cause APO, and the effect of periodontal therapy during pregnancy on birth outcomes.
口腔微生物群失调，由口腔病原体增加或有益菌减少引发，会导致口腔和全身性疾病。近期的生态学研究表明，牙周病是不良妊娠结局的一个风险因素。口腔微生物群失调被认为与口腔疾病和不良妊娠结局（APO）相关。然而，其致病机制尚未阐明。在这篇综述中，我们总结了近期关于妊娠相关的致病性口腔微生物群失调如何引发妊娠期牙周疾病和不良分娩结局的文献，特别是牙周病原菌在妊娠期牙周疾病导致APO的机制中的作用，以及孕期牙周治疗对分娩结局的影响。
