Suzhou Medical College of Soochow University, Suzhou, China.
Department of Obstetrics and Gynecology, The First People's Hospital of Kunshan Affiliated With Jiangsu University, Suzhou, China.
Front Public Health. 2022 May 27;10:878845. doi: 10.3389/fpubh.2022.878845. eCollection 2022.
The association between gestational diabetes mellitus (GDM) and the risk of arthritis has not been reported. GDM increases the risk of long-term complications including diabetes and metabolic syndrome that are positively associated with the risk of arthritis. This study aimed to explore the association between GDM and the risk of arthritis.
Women (age ≥ 20 years) who had delivered at least one live birth were included from the 2007 to 2018 National Health and Nutrition Examination Survey cohort ( = 11,997). Patients who had a history of GDM and arthritis were identified by in-home interview. Subgroup analyses were conducted by arthritis types and status of obesity, current diabetes, metabolic syndrome, smoking, alcohol drinking, and physical activity.
GDM was associated with increased odds of arthritis [multivariable-adjusted odds ratio (95% confidence interval): 1.31 (1.06-1.62)], and the result was similar in sensitivity analysis with further adjustment for metabolic syndrome [1.30 (1.05-1.60)]. In subgroup analyses, GDM was associated with increased odds of osteoarthritis [1.47 (1.05-2.06)], while no association was observed with rheumatoid arthritis [1.04 (0.69-1.57)] and other types [1.26 (0.94-1.68)]. GDM was associated with increased odds of arthritis in women without metabolic syndrome [1.34 (1.00-1.78)] and diabetes [1.35 (1.03-1.76)], in obese individuals [1.64 (1.24-2.16)], current/former smokers [1.43 (1.05-1.95)], and current drinkers [1.76 (1.00-3.14)], and in individuals engaging in higher levels of physical activity [1.53 (1.06-2.20)].
GDM was associated with increased odds of arthritis, and the association was independent of type 2 diabetes and metabolic syndrome.
妊娠期糖尿病（GDM）与关节炎风险之间的关联尚未有报道。GDM 会增加长期并发症的风险，包括糖尿病和代谢综合征，这些疾病与关节炎的风险呈正相关。本研究旨在探讨 GDM 与关节炎风险之间的关系。
我们从 2007 年至 2018 年的全国健康和营养调查队列中纳入了至少分娩过一胎的年龄≥20 岁的女性（n=11997）。通过家庭访谈确定患有 GDM 和关节炎病史的患者。通过关节炎类型和肥胖、当前糖尿病、代谢综合征、吸烟、饮酒和身体活动状况进行亚组分析。
GDM 与关节炎的发病风险增加相关（多变量调整后的优势比[95%置信区间]：1.31[1.06-1.62]），进一步调整代谢综合征后，结果在敏感性分析中仍相似[1.30[1.05-1.60]）。在亚组分析中，GDM 与骨关节炎的发病风险增加相关（1.47[1.05-2.06]），而与类风湿关节炎[1.04[0.69-1.57]）和其他类型[1.26[0.94-1.68]）无关。在没有代谢综合征和糖尿病的女性、肥胖患者、当前/曾经吸烟者、当前饮酒者以及身体活动水平较高的个体中，GDM 与关节炎的发病风险增加相关（无代谢综合征：1.34[1.00-1.78]；糖尿病：1.35[1.03-1.76]；肥胖：1.64[1.24-2.16]；当前/曾经吸烟者：1.43[1.05-1.95]；当前饮酒者：1.76[1.00-3.14]；身体活动水平较高：1.53[1.06-2.20]）。
GDM 与关节炎的发病风险增加有关，且这种关联独立于 2 型糖尿病和代谢综合征。
