Faculty of Medicine and Health Sciences, School of Dentistry, University of Barcelona, IDIBELL (Bellvitge Biomedical Research Institute), 08907 Barcelona, Spain.
Department of Cardiology, Hospital Universitari Vall d'Hebron, Autonomous University of Barcelona, 08035 Barcelona, Spain.
Biomed Res Int. 2022 Jun 1;2022:6238099. doi: 10.1155/2022/6238099. eCollection 2022.
Periodontitis is an inflammatory condition caused by a bacterial plaque and characterized by progressive destruction of the tooth-supporting apparatus. Patients with Marfan syndrome (MFS) exhibit a connective tissue disorder, which can also affect oral soft and hard tissue. Thus, the aims of this cross-sectional study were to assess the association between periodontitis and MFS and secondly, to compare periodontal parameters and prevalence of disease with a control group (CG) without MFS. 152 patients (MFS = 76, CG = 76) were recruited to evaluate the following periodontal parameters: probing depth, gingival margin, clinical attachment level, plaque index, and bleeding on probing. The 2017 World Workshop guideline was followed for the diagnosis of the periodontal status. A multivariate analysis was performed using a multinomial logistic regression adjusted for age, gender, and smoking. The level of significance required was < 0.05. Patients with MFS did not show a higher prevalence of periodontitis compared to the CG. However, patients with MFS did have higher values in probing depth, gingival recession, clinical attachment level, and plaque index compared to the CG patients ( < 0.05). In conclusion, although similar prevalence of periodontitis was found among the studied groups, MFS patients showed worse periodontal parameters.
牙周炎是一种由细菌斑块引起的炎症性疾病，其特征是牙齿支持组织的进行性破坏。马凡综合征（MFS）患者表现出结缔组织疾病，也会影响口腔软硬组织。因此，本横断面研究旨在评估牙周炎与 MFS 之间的关联，并其次比较牙周参数和疾病的患病率与无 MFS 的对照组（CG）。招募了 152 名患者（MFS=76，CG=76）来评估以下牙周参数：探诊深度、牙龈边缘、临床附着水平、菌斑指数和探诊出血。牙周状况的诊断遵循了 2017 年世界牙周病工作坊指南。使用调整了年龄、性别和吸烟状况的多项逻辑回归进行了多变量分析。要求的显著性水平为 < 0.05。与 CG 相比，MFS 患者的牙周炎患病率并没有更高。然而，与 CG 患者相比，MFS 患者的探诊深度、牙龈退缩、临床附着水平和菌斑指数更高（<0.05）。总之，尽管在研究组中发现了相似的牙周炎患病率，但 MFS 患者的牙周参数更差。
