Wang Qiwei, Wang Fang, Zhao Yinan, Tan Guolin
Department Otolaryngology Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Otorhinolaryngology, Klinikum Rechts der Isar of the Technical University of Munich, Munich, Germany.
Front Genet. 2022 May 25;13:862143. doi: 10.3389/fgene.2022.862143. eCollection 2022.
The latest research suggesting that necroptosis plays a vital role in immune response. However, the influence of necroptosis on tumor microenvironment (TME) remodeling and immunotherapy is still unclear. We analyzed the variations in the expression of 26 necroptosis-related molecules in HNSCC and the influence of genome changes. We investigated HNSCC samples and determined that there are two necroptosis phenotypes in HNSCC cancer, and there are significant differences in cell infiltration characteristics and survival in different necroptosis phenotypes. We used the single-sample gene set enrichment analysis to measure the level of necroptosis in patients with NecroticScore, we confirmed that the NecroticScore can predict the prognosis of HNSCC patients and the response to immunotherapy. Patients with a high NecroticScore are more sensitive to immunotherapy and have a better prognosis. Our study suggests a significant correlation between the expression imbalance of necroptosis-related molecules and suggests necroptosis plays an important role in modeling the TME. In addition, we construct a risk prediction model which could stratify patients with HNSCC and predict patient prognosis according to this necroptosis-related molecules. In conclusion, evaluating necroptosis modification patterns contributes to enhancing our understanding of TME and can guide more effective immunotherapy strategies.
最新研究表明，坏死性凋亡在免疫反应中起着至关重要的作用。然而，坏死性凋亡对肿瘤微环境（TME）重塑和免疫治疗的影响仍不清楚。我们分析了头颈部鳞状细胞癌（HNSCC）中26种坏死性凋亡相关分子表达的变化以及基因组改变的影响。我们研究了HNSCC样本，确定HNSCC癌症存在两种坏死性凋亡表型，不同坏死性凋亡表型的细胞浸润特征和生存率存在显著差异。我们使用单样本基因集富集分析通过坏死性评分（NecroticScore）来衡量患者的坏死性凋亡水平，我们证实坏死性评分可以预测HNSCC患者的预后和对免疫治疗的反应。坏死性评分高的患者对免疫治疗更敏感，预后更好。我们的研究表明坏死性凋亡相关分子表达失衡之间存在显著相关性，并表明坏死性凋亡在TME建模中起重要作用。此外，我们构建了一个风险预测模型，该模型可以对HNSCC患者进行分层，并根据这些坏死性凋亡相关分子预测患者预后。总之，评估坏死性凋亡修饰模式有助于增强我们对TME的理解，并可指导更有效的免疫治疗策略。
