is a Potential Biomarker for Poor Prognosis in Lung Adenocarcinoma.

Recent studies have demonstrated that creatine can promote tumor metastasis and has implications for immune cell function. encodes a membrane protein that can transport creatine inside and outside the cell. However, there are currently no studies of in lung adenocarcinoma (LUAD). In this study, the expression of in LUAD was analyzed using the Oncomine database, the Cancer Genome Atlas (TCGA) database, and immunohistochemical staining analysis. Survival analysis of patients with LUAD was performed using the cBioPortal and the Kaplan-Meier Plotter websites and clinical follow-up data. An analysis of the association between and the tumor immune microenvironment (TIME) of LUAD was performed through the TISIDB database and estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) algorithm. Then, based on the curated list of -related immunomodulators, three genes () were selected to construct -related immune signatures to further evaluate the immune aspect of LUAD prognosis. Our studies indicated that was overexpressed in LUAD, and the high expression of was associated with poor survival. Genetic alteration of was also associated with a poorer prognosis. Furthermore, multivariate Cox analysis indicated that could be used as an independent risk prognostic factor. Then, immune infiltration analysis indicated that was also strongly associated with poor prognosis in the TIME of LUAD. A multivariate Cox proportional hazard model was then constructed, and was shown effective at identifying high-risk patients. Univariate and multivariate Cox analysis showed that the risk scoring of the model was an independent prognostic risk factor in LUAD. may serve as a biomarker for poor prognosis in LUAD.