二甲双胍对糖尿病肾病患者肾功能、心功能及炎症反应的影响及其保护机制。
Effects of Metformin on Renal Function, Cardiac Function, and Inflammatory Response in Diabetic Nephropathy and Its Protective Mechanism.
机构信息
Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Rheumatology and Immunology, Shijingshan Teaching Hospital of Capital Medical University, Beijing Shijingshan Hospital, Beijing 100043, China.
出版信息
Dis Markers. 2022 Jun 3;2022:8326767. doi: 10.1155/2022/8326767. eCollection 2022.
OBJECTIVE
To investigate the effect of metformin on renal function, cardiac function, and inflammatory response in diabetic nephropathy and its protective mechanism.
METHODS
A total of 88 patients with diabetic nephropathy who were admitted to our hospital from April 2019 to October 2020 were recruited and grouped according to different treatment methods, namely, the experimental group ( = 44) and the control group ( = 44). The patients in the experimental group were treated with metformin, and the patients in the control group were treated with liraglutide injection (nonmetformin). Left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), and inflammatory response (hs-CRP, TNF-, IL-6) were compared.
RESULTS
Compared with corresponding values before treatment, BUN, Scr, hs-CRP, TNF-, IL-6, LVEDD, and LVESD were decreased after treatment, whereas LVEF was increased (all < 0.05), with significant change in the experimental group (all < 0.001).
CONCLUSION
Metformin can effectively improve the level of renal function and cardiac function in patients with diabetic nephropathy and help patients control and reduce the body's inflammatory response, and its therapeutic efficacy is superior to that of liraglutide injection.
目的
探讨二甲双胍对糖尿病肾病患者肾功能、心功能和炎症反应的影响及其保护机制。
方法
选取 2019 年 4 月至 2020 年 10 月我院收治的 88 例糖尿病肾病患者，按不同治疗方法分为实验组（n=44）和对照组（n=44）。实验组患者给予二甲双胍治疗，对照组患者给予利拉鲁肽注射液（非二甲双胍类）治疗。比较两组左心室舒张末期直径（LVEDD）、左心室射血分数（LVEF）、左心室收缩末期直径（LVESD）和炎症反应（hs-CRP、TNF-α、IL-6）。
结果
与治疗前相应值比较，两组治疗后 BUN、Scr、hs-CRP、TNF-α、IL-6、LVEDD 和 LVESD 降低，LVEF 升高（均 P<0.05），且实验组变化更显著（均 P<0.001）。
结论
二甲双胍可有效改善糖尿病肾病患者的肾功能和心功能，有助于控制和降低机体的炎症反应，其疗效优于利拉鲁肽注射液。
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