Princess Noorah Oncology Center, National Guard Health Affairs (NGHA), King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Centre (KAIMRC), King Abdulaziz Medical City, Jeddah, Saudi Arabia.
Department Medical Education, College of Medicine, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Centre (KAIMRC), National Guard Health Affairs (NGHA), King Abdulaziz Medical City, Jeddah, Saudi Arabia.
Dis Markers. 2022 Jun 3;2022:4354595. doi: 10.1155/2022/4354595. eCollection 2022.
Graves' disease (GD) and Hashimoto's thyroiditis (HT) are the most common types of autoimmune thyroid diseases (AITD), and both are characterized by the infiltration of lymphocytes into the thyroid gland. Moreover, autoimmune diseases like HT have a higher risk of developing lymphoma. This study is aimed at assessing the prevalence and association of lymphoma in patients with AITD.
This cross-sectional study was conducted in King Abdulaziz Medical City, Jeddah, Saudi Arabia. Data were gathered from the medical records of patients aged 18 years or older who developed AITD. A total number of 140 medical records were collected, and 72 patients were included after applying in exclusion criteria. Data on the subtype, clinical-stage, treatment modality, patient status, remission, and relapse were collected for patients who developed lymphoma.
Among 72 patients who developed AITD, HT was diagnosed in 58 (80.6%) patients and GD in 14 (19.4%). Five (7%) patients were diagnosed with lymphoma all of whom had a history of HT. The subtypes of lymphoma were diffuse large B-cell lymphoma (DLBCL 3; 4.2%), follicular lymphoma 1 (1.4%), and Hodgkin's lymphoma 1 (1.4%).
The prevalence of PTL in patients with AITD, specifically HT, was 7%. Most patients developed NHL, with DLBCL being the most common subtype. The onset of lymphoma in this study was lower than reported in the literature. All patients with PTL had HT in their backgrounds. Further national studies are warranted to explore the relationship between the two diseases to provide more insight into the comprehension of this association.
格雷夫斯病（GD）和桥本甲状腺炎（HT）是最常见的自身免疫性甲状腺疾病（AITD），其特征均为淋巴细胞浸润甲状腺。此外，HT 等自身免疫性疾病发生淋巴瘤的风险更高。本研究旨在评估 AITD 患者中淋巴瘤的患病率和相关性。
这是一项在沙特阿拉伯吉达阿卜杜勒阿齐兹国王医疗城进行的横断面研究。从年龄在 18 岁及以上发生 AITD 的患者的病历中收集数据。共收集了 140 份病历，应用排除标准后纳入了 72 名患者。收集了发生淋巴瘤的患者的亚型、临床分期、治疗方式、患者状况、缓解和复发的数据。
在发生 AITD 的 72 名患者中，58 名（80.6%）患者诊断为 HT，14 名（19.4%）患者诊断为 GD。5 名（7%）患者诊断为淋巴瘤，均有 HT 病史。淋巴瘤的亚型为弥漫性大 B 细胞淋巴瘤（DLBCL 3；4.2%）、滤泡性淋巴瘤 1（1.4%）和霍奇金淋巴瘤 1（1.4%）。
AITD 患者，特别是 HT 患者的 PTL 患病率为 7%。大多数患者发生 NHL，最常见的亚型为 DLBCL。本研究中淋巴瘤的发病较低于文献报道。所有 PTL 患者的背景中均有 HT。需要进一步进行全国性研究，以探讨这两种疾病之间的关系，从而更深入地了解这种关联。
