Mancuso Salvatrice, Carlisi Melania, Napolitano Mariasanta, Siragusa Sergio
Department of Oncology, Haematology Unit, University of Palermo School of Medicine, Palermo, Italy.
Hematol Oncol. 2018 Feb 27. doi: 10.1002/hon.2504.
The thyroid gland is often involved in the development of neoplastic diseases, including lymphoproliferative disorders. The aim of this paper is to provide a comprehensive overview of the multiple interactions between lymphoma and thyroid. Through an extensive research among the literature, the relationship between lymphomas and thyroid can be established at various levels, and the possible interconnections are here summarized in 5 points: (1) the greater risk of lymphoma development in some thyroid diseases; (2) the primary thyroid lymphoma, with focus on issues related to the diagnosis, differential diagnosis, and treatment; (3) the incidence of thyroid involvement in primitive nodal lymphomas or in extranodal lymphomas of the other sites; (4) thyroid changes after treatment of lymphoma, in relation to the effects of radiation therapy and immuno-chemotherapy; (5) the incidental findings of thyroid changes, on imaging, in patients with lymphoma, without a direct involvement of the gland in malignant disease. In conclusion, issues that until now have been dealt with separately will therefore be analyzed in a unique paper, allowing a global view of the topic and emphasizing the need of a multidisciplinary approach. Future learning areas in this topic mainly relate to rapidly increasing the knowledge of imaging studies together with expanding the armamentarium of novel biological and targeting agents in lymphoma patients.
甲状腺常参与肿瘤性疾病的发生发展，包括淋巴增殖性疾病。本文旨在全面概述淋巴瘤与甲状腺之间的多种相互作用。通过对文献的广泛研究，淋巴瘤与甲状腺之间的关系可在多个层面得以确立，现将可能的相互联系总结为以下5点：（1）某些甲状腺疾病中淋巴瘤发生风险较高；（2）原发性甲状腺淋巴瘤，重点关注诊断、鉴别诊断及治疗相关问题；（3）原发性结内淋巴瘤或其他部位结外淋巴瘤累及甲状腺的发生率；（4）淋巴瘤治疗后甲状腺的变化，与放射治疗及免疫化疗的效果相关；（5）淋巴瘤患者影像学检查偶然发现的甲状腺变化，而腺体未直接受恶性疾病累及。总之，本文将对迄今一直分别论述的问题进行综合分析，从而对该主题有一个全面的认识，并强调多学科方法的必要性。该主题未来的研究领域主要涉及迅速增加影像学研究知识，以及扩充淋巴瘤患者新型生物制剂和靶向药物的种类。
