Zakernezhad Forogh, Barati Mahmood, Sanadgol Nima, Movahhedi Monireh, Majd Ahmad, Golab Fereshteh
Department of Cellular and Molecular Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Department of Biotechnology, School of Allied Medicine, Iran University of Medical Science, Tehran, Iran.
Basic Clin Neurosci. 2021 Nov-Dec;12(6):711-720. doi: 10.32598/bcn.2021.998.2. Epub 2021 Nov 1.
Obesity is among the most severe challenges of our era, with significant health consequences and a high economic burden for health systems. Therefore, many countries have developed political agendas to cope with this ever-rising challenge. Along with chemical medications developed to manage obesity, researchers have focused on some natural ingredients and herbal extracts that are effective in reducing weight. The current study investigated the association between Foeniculum vulgar (fennel) extracts and body weight, lipid profile, and leptin.
In total, 35 adult male BALB/c mice were investigated in sham, fennel 50 mg/kg, fennel 100 mg/kg, and fennel 200 mg/kg (n=7) groups. The mice were administered fennel extracts for fourteen days while weighted at the intervention's beginning and end. Then, their weight, lipid profile, serum leptin, and expression of leptin protein in the hypothalamus were measured.
After providing the intervention, leptin receptor protein expression was increased in all groups, while serum leptin didn't change significantly. Moreover, a significant decrease was observed in the cholesterol dose of 100 mg/kg/day, triglycerides in 100 and 200 mg/kg/day, and LDL in 50 and 100 mg/kg/day. Serum HDL was increased significantly in a dose of 100 mg/kg/day.
Fennel extract can decrease the lipid profile by changing the expression of the leptin receptor.
Obesity contributes to many health problems and dyslipidemia.Leptin is known for its hunger-blocking can regulate food intake and affects the levels of lipid. circulation.Fennel is a plant with strong antioxidant activities [18] that can influence (increase) satiety and (reduce) food intake.Fennel contains phytosterols that are known to reduce cholesterol solubilization that in turn decreases its absorption.Fennel extract can improve the lipid profile by influencing the leptin receptor expression.
Obesity is one of the most serious challenges of our era, with significant health consequences. Researchers have focused on some natural ingredients and herbal extracts. The current study aimed to investigate the association between Foeniculum vulgar (fennel) extracts and body weight, lipid profile, and leptin. After treatment of fennel, leptin receptor protein expression was increased in all groups, while serum leptin didn't change significantly. A significant decrease was observed in the cholesterol, triglycerides and LDL in some doses of fennel. Serum HDL was increased significantly in a dose of 100 mg/kg/day. So fennel extract can decrease the lipid profile by changing the expression of the leptin receptor.
肥胖是我们这个时代最严峻的挑战之一，会带来严重的健康后果，并给卫生系统造成高昂的经济负担。因此，许多国家已制定政治议程来应对这一日益严峻的挑战。除了研发用于控制肥胖的化学药物外，研究人员还关注了一些对减轻体重有效的天然成分和草药提取物。本研究调查了小茴香提取物与体重、血脂谱和瘦素之间的关联。
总共35只成年雄性BALB/c小鼠被分为假手术组、50毫克/千克小茴香组、100毫克/千克小茴香组和200毫克/千克小茴香组（每组n = 7）。给小鼠服用小茴香提取物14天，在干预开始和结束时称重。然后，测量它们的体重、血脂谱、血清瘦素以及下丘脑瘦素蛋白的表达。
提供干预后，所有组的瘦素受体蛋白表达均增加，而血清瘦素没有显著变化。此外，观察到100毫克/千克/天剂量的胆固醇、100和200毫克/千克/天剂量的甘油三酯以及50和100毫克/千克/天剂量的低密度脂蛋白有显著下降。100毫克/千克/天剂量的血清高密度脂蛋白显著增加。
小茴香提取物可通过改变瘦素受体的表达来降低血脂谱。
肥胖会导致许多健康问题和血脂异常。瘦素以其抑制饥饿的作用而闻名，可调节食物摄入量并影响血脂水平。小茴香是一种具有强大抗氧化活性的植物，可影响（增加）饱腹感并（减少）食物摄入量。小茴香含有植物甾醇，已知其可降低胆固醇的溶解性，进而减少其吸收。小茴香提取物可通过影响瘦素受体表达来改善血脂谱。
肥胖是我们这个时代最严重的挑战之一，会带来重大健康后果。研究人员关注了一些天然成分和草药提取物。本研究旨在调查小茴香提取物与体重、血脂谱和瘦素之间的关联。用小茴香治疗后，所有组的瘦素受体蛋白表达均增加，而血清瘦素没有显著变化。在某些小茴香剂量下，胆固醇、甘油三酯和低密度脂蛋白有显著下降。100毫克/千克/天剂量的血清高密度脂蛋白显著增加。因此，小茴香提取物可通过改变瘦素受体的表达来降低血脂谱。
