Department of Paediatrics, Zhejiang Putuo Hospital, Zhoushan, 316100 Zhejiang, China.
Comput Math Methods Med. 2022 Jun 1;2022:7007370. doi: 10.1155/2022/7007370. eCollection 2022.
The data mining analysis of the medication rule and the curative effect of traditional Chinese medicine in treating allergic rhinitis in children was performed by using the association rule Apriori algorithm. The model of interest degree was introduced to improve the Apriori algorithm, and the performance difference of the algorithm before and after improvement was analyzed. Traditional Chinese medicine prescriptions for the treatment of allergic rhinitis in children were selected from the dictionary of Chinese medicine formulations. The frequency, frequent itemsets, and the improved Apriori algorithm of each prescription were analyzed comprehensively. The results showed that both the execution time of the improved Apriori algorithm and the number of mining association rules were signally lower. 102 Chinese herbal compounds were selected, in which the occurrence frequency of Flos magnoliae was the highest (67 times, 5.33%). The occurrence frequency of diaphoretic drugs was the highest (412 times, 32.78%) in drug types. The occurrence frequency of Yu Ping Feng powder was the highest (21 times, 20.59%) in the Chinese herbal compound. After the association rule analysis of the improved Apriori algorithm, Perilla frutescens, Saposhnikovia divaricata, ginseng, Notopterygium root, and Astragalus propinquus Schischkin were often mixed with liquorice, and Flos magnoliae were usually mixed with Fructus xanthii and black plum. Compared with the conditions before treatment, the sign scores of children with allergic rhinitis were remarkably decreased after treatment with traditional Chinese medicine compounds ( < 0.05). The mining performance of the Apriori algorithm was improved by introducing an interest-based model. The treatment of traditional Chinese medicine on allergic rhinitis in children was combined with children's physiological and pathological characteristics of children, which used mild medicines.
采用关联规则 Apriori 算法对治疗儿童变应性鼻炎的中药用药规律和疗效进行数据挖掘分析。引入兴趣度模型对 Apriori 算法进行改进,并分析算法改进前后的性能差异。从中药方剂数据库中选取治疗儿童变应性鼻炎的中药方剂,对各处方的频次、频繁项集及改进后的 Apriori 算法进行综合分析。结果表明,改进后的 Apriori 算法的执行时间和挖掘关联规则的数量均显著降低。共筛选出 102 种中药复方,其中使用频次最高的中药为辛夷(67 次,5.33%),药类中使用频次最高的为解表药(412 次,32.78%),中药复方中使用频次最高的为玉屏风散(21 次,20.59%)。经过改进的 Apriori 算法关联规则分析,荆芥、防风、人参、羌活、黄芪常与甘草合用,辛夷常与苍耳子、乌梅合用。与治疗前相比,儿童变应性鼻炎经中药复方治疗后,其症状评分显著降低(<0.05)。通过引入基于兴趣度的模型,改进了 Apriori 算法的挖掘性能。结合儿童的生理病理特点,运用温和的药物对儿童变应性鼻炎进行中医治疗。