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肠道固有神经元中的血管活性肠肽、脑啡肽、P物质和生长抑素样免疫反应性：来自器官型组织培养的免疫组织化学证据

VIP-, enkephalin-, substance P- and somatostatin-like immunoreactivity in neurons intrinsic to the intestine: immunohistochemical evidence from organotypic tissue cultures.

作者信息

Schultzberg M, Dreyfus C F, Gershon M D, Hökfelt T, Elde R P, Nilsson G, Said S, Goldstein M

出版信息

Brain Res. 1978 Oct 27;155(2):239-48. doi: 10.1016/0006-8993(78)91020-x.

DOI:10.1016/0006-8993(78)91020-x
PMID:356933
Abstract

Small intestine from 18-day fetal mice grown for 3 weeks in organotypic tissue culture was found to contain numerous VIP, enkephalin, substance P and some somatostatin immunoreactive nerve fibers. Since these cultures should be devoid of all afferent or other extrinsic neuronal inputs, it is concluded that there are VIP, enkephalin, substance P and somatostatin containing neurons intrinsic to the intestinal wall. However, all 4 peptides may also be present in neurons originating outside the gastrointestinal tract as well as in the intrinsic neurons.

摘要

在器官型组织培养中生长3周的18天龄胎鼠小肠，被发现含有大量血管活性肠肽（VIP）、脑啡肽、P物质和一些生长抑素免疫反应性神经纤维。由于这些培养物应该没有所有传入或其他外在神经输入，因此得出结论，肠壁内存在含有VIP、脑啡肽、P物质和生长抑素的内在神经元。然而，所有这4种肽也可能存在于源自胃肠道外的神经元以及内在神经元中。

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引用本文的文献

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Pediatr Surg Int. 1996 Dec;11(1):33-40. doi: 10.1007/BF00174582. Epub 2013 Sep 21.
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Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons.神经营养因子-3是发育中的肠神经元亚群存活分化所必需的。
J Neurosci. 2001 Aug 1;21(15):5620-36. doi: 10.1523/JNEUROSCI.21-15-05620.2001.
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Cell Tissue Res. 1981;220(2):231-8. doi: 10.1007/BF00210505.
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Gut. 1982 Jan;23(1):63-5. doi: 10.1136/gut.23.1.63.
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J Neural Transm. 1984;59(3):195-205. doi: 10.1007/BF01250008.
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