Viatris, 1000 Mylan Boulevard, Canonsburg, PA 15317, USA.
School of Pharmacy, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, Belfast, UK.
Int J Clin Pract. 2022 Mar 20;2022:5229702. doi: 10.1155/2022/5229702. eCollection 2022.
Assessment of erectile dysfunction (ED) burden could improve health outcomes associated with underlying cardiometabolic and psychological causes of ED. This study provided updated real-world evidence (RWE) on ED epidemiology and quantified healthcare resource utilization (HCRU) and health-related quality of life (HRQoL) burden among men with ED in the UK.
This cross-sectional, prospective real-world evidence study was conducted via a self-reported Internet survey in 2018 in the UK general population. Prevalence of ED was estimated; HCRU and HRQoL were compared between men with ED versus without ED via bivariate analysis.
Of 12,490 men included, 41.5% reported ED; 7.5% of men reported severe ED; ED was most prevalent in Wales (44.3%). Men with ED were older (54.1 ± 14.5 vs. 46.8 ± 14.1 years) and often reported modifiable lifestyle risk factors, including smoking (32.8% vs. 26.3%), drinking alcohol (76.1% vs. 71.0%), not exercising (21.7% vs. 19.4%), and being overweight or obese (64.9% vs. 54.6%). Additionally, men with ED more often reported ≥1 comorbid chronic conditions (73.7% vs. 47.7%), including hypertension (31.8% vs. 16.3%), hyperlipidemia (27.6% vs. 14.0%), depression (24.3% vs. 14.6%), anxiety (23.3% vs. 16.6%), and diabetes (15.9% vs. 6.1%) versus men without ED (all, < 0.001). Nearly half of men with ED (45.3%) were not undergoing treatment for cardiometabolic or psychological comorbidities. Furthermore, men with ED more often reported ≥1 visit to physicians/nurse practitioners and pharmacists in the past year and had significantly lower SEAR total and domain scores than men without ED (all, < 0.001).
ED was highly prevalent in the UK affecting over a quarter of younger men. Cardiometabolic and psychological conditions were common among men with ED and often remained untreated. Higher proportions of modifiable lifestyle risk factors observed among men with ED present an opportunity for healthcare providers to help mitigate the risk of cardiometabolic diseases and incidence of ED.
评估勃起功能障碍（ED）的负担可以改善与 ED 潜在的心血管代谢和心理原因相关的健康结果。本研究提供了英国 ED 流行病学的最新真实世界证据（RWE），并量化了 ED 男性的医疗资源利用（HCRU）和健康相关生活质量（HRQoL）负担。
这是一项通过 2018 年在英国普通人群中进行的自我报告互联网调查进行的横断面、前瞻性真实世界证据研究。估计 ED 的患病率；通过双变量分析比较 ED 男性与无 ED 男性之间的 HCRU 和 HRQoL。
在纳入的 12490 名男性中，41.5%报告有 ED；7.5%的男性报告有严重 ED；威尔士 ED 的患病率最高（44.3%）。ED 男性年龄较大（54.1±14.5 岁 vs. 46.8±14.1 岁），并且经常报告可改变的生活方式危险因素，包括吸烟（32.8% vs. 26.3%）、饮酒（76.1% vs. 71.0%）、不锻炼（21.7% vs. 19.4%）和超重或肥胖（64.9% vs. 54.6%）。此外，ED 男性更常报告有≥1 种合并的慢性疾病（73.7% vs. 47.7%），包括高血压（31.8% vs. 16.3%）、高脂血症（27.6% vs. 14.0%）、抑郁症（24.3% vs. 14.6%）、焦虑症（23.3% vs. 16.6%）和糖尿病（15.9% vs. 6.1%），而无 ED 的男性（均<0.001）。近一半的 ED 男性（45.3%）没有接受针对心血管代谢或心理合并症的治疗。此外，ED 男性过去一年中去医生/护士从业者和药剂师就诊的次数更多，并且 SEAR 总分和各领域得分明显低于无 ED 的男性（均<0.001）。
ED 在英国非常普遍，影响了超过四分之一的年轻男性。心血管代谢和心理疾病在 ED 男性中很常见，且往往未得到治疗。ED 男性中观察到的可改变的生活方式危险因素比例较高，为医疗保健提供者提供了一个机会，帮助减轻心血管代谢疾病的风险和 ED 的发生率。
