Kraiuhin C, Gordon E, Stanfield P, Meares R, Howson A
Exp Aging Res. 1986 Winter;12(4):187-92. doi: 10.1080/03610738608258566.
A tone discrimination task was used to elicit the P300 component of event related potentials in 55 normal subjects aged between 15 and 89 years. The age/latency relationship in the total sample was significant, but contrary to the reports of some others was statistically better described at CZ by a linear and not a curvilinear age regression function. Adults over 45 had steeper age regression slopes and larger age/latency correlations frontally and centrally than younger adults, but there was no difference in amplitude between these groups. The effect of age on latency seemed slightly more pronounced frontally in older adults, and there was significantly more latency variability in this group. Overall, the age/latency relationship in adults was statistically best described by separate linear age regression functions for adults less than or equal to 45 and greater than 45. It is suggested that latency variability may account for some of the discrepancy in the age/P300 literature, and the clinical implications of this are discussed.
采用音调辨别任务来诱发55名年龄在15至89岁之间的正常受试者的事件相关电位P300成分。总样本中的年龄/潜伏期关系具有显著性，但与其他一些报告相反，在CZ电极点，用线性而非曲线年龄回归函数对其进行统计学描述效果更好。45岁以上的成年人比年轻成年人在额叶和中央区域有更陡峭的年龄回归斜率以及更大的年龄/潜伏期相关性，但这些组之间的波幅没有差异。年龄对潜伏期的影响在老年人的额叶似乎更为明显，并且该组的潜伏期变异性显著更大。总体而言，对于年龄小于或等于45岁和大于45岁的成年人，用单独的线性年龄回归函数对其年龄/潜伏期关系进行统计学描述效果最佳。研究表明，潜伏期变异性可能是年龄/P300文献中一些差异的原因，并讨论了其临床意义。
