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魁北克省用于疼痛管理的大麻使用情况:合法化后对慢性疼痛患者各代人群的估计

Prevalence of cannabis use for pain management in Quebec: A post-legalization estimate among generations living with chronic pain.

作者信息

Godbout-Parent Marimée, Nguena Nguefack Hermine Lore, Angarita-Fonseca Adriana, Audet Claudie, Bernier Andréanne, Zahlan Ghita, Julien Nancy, Pagé M Gabrielle, Guénette Line, Blais Lucie, Lacasse Anaïs

机构信息

Département des sciences de la santé, Université du Québec en Abitibi-Témiscamingue (UQAT), Rouyn-Noranda, Québec, Canada.

Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.

出版信息

Can J Pain. 2022 Jun 3;6(1):65-77. doi: 10.1080/24740527.2022.2051112. eCollection 2022.

Abstract

BACKGROUND

Medical cannabis has been legal in Canada since 2001, and recreational cannabis was legalized in October 2018, which has led to a widespread increase in the accessibility of cannabis products.

AIMS

This study aimed to estimate the prevalence of cannabis use among adults living with chronic pain (CP) and investigate the relationship between age and cannabis use for CP management.

METHODS

A cross-sectional analysis of the COPE Cohort data set, a large Quebec sample of 1935 adults living with CP, was conducted. Participants completed a web-based questionnaire in 2019 that contained three yes/no questions about past-year use of cannabis (i.e., for pain management, management of other health-related conditions, recreational purposes).

RESULTS

Among the 1344 participants who completed the cannabis use section of the questionnaire, the overall prevalence of cannabis use for pain management was 30.1% (95% confidence interval 27.7-32.7). Differences were found between age groups, with the highest prevalence among participants aged ≤26 years (36.5%) and lowest for those aged ≥74 years (8.8%). A multivariable logistic model revealed that age, region of residence, generalized pain, use of medications or nonpharmacological approaches for pain management, alcohol/drug consumption, and smoking were associated with the likelihood of using cannabis for pain management.

CONCLUSIONS

Cannabis is a common treatment for the management of CP, especially in younger generations. The high prevalence of use emphasizes the importance of better knowledge translation for people living with CP, rapidly generating evidence regarding the safety and efficacy of cannabis, and clinicians' involvement in supporting people who use cannabis for pain management.

摘要

背景

自2001年起医用大麻在加拿大合法化,2018年10月娱乐用大麻也实现合法化,这使得大麻产品的可及性普遍增加。

目的

本研究旨在估计慢性疼痛(CP)成年患者中大麻使用的流行率,并调查年龄与用于CP管理的大麻使用之间的关系。

方法

对COPE队列数据集进行横断面分析,该数据集来自魁北克的一个包含1935名CP成年患者的大样本。参与者于2019年完成了一份基于网络的问卷,其中包含三个关于过去一年大麻使用情况的是/否问题(即用于疼痛管理、其他健康相关状况管理、娱乐目的)。

结果

在完成问卷中大麻使用部分的1344名参与者中,用于疼痛管理的大麻使用总体流行率为30.1%(95%置信区间27.7 - 32.7)。各年龄组之间存在差异,年龄≤26岁的参与者中流行率最高(36.5%),≥74岁的参与者中流行率最低(8.8%)。多变量逻辑模型显示,年龄、居住地区、全身性疼痛、用于疼痛管理的药物或非药物方法的使用、酒精/药物消费以及吸烟与使用大麻进行疼痛管理的可能性相关。

结论

大麻是CP管理的常用治疗方法,尤其是在年轻一代中。高使用率强调了对CP患者进行更好的知识转化、快速生成关于大麻安全性和有效性的证据以及临床医生参与支持使用大麻进行疼痛管理的患者的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ca/9176231/334f4d78ab87/UCJP_A_2051112_F0001_B.jpg

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