Lewis-Thompson India, Zhang Shaoyan, Noimark Sacha, Desjardins Adrien E, Colchester Richard J
Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT UK.
Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, Charles Bell House, Foley Street, London, W1W 7TY UK.
MRS Adv. 2022;7(23-24):499-503. doi: 10.1557/s43580-022-00208-3. Epub 2022 Jan 18.
All-optical ultrasound (OpUS) imaging has emerged as an imaging paradigm well-suited for minimally invasive surgical procedures. With this modality, ultrasound is generated when pulsed or modulated light is absorbed within a coating material. By engineering wavelength-selective coatings, complementary imaging and therapeutic modalities can be integrated with OpUS. Here, we present a wavelength-selective composite material comprising a near-infrared absorbing dye and polydimethylsiloxane. The optical absorption for this material peaked in the vicinity of 1064 nm, with up to 91% of incident light being absorbed, whilst maintaining lower optical absorption at other wavelengths. This material was used to generate ultrasound, demonstrating ultrasound pressures MPa, consistent with those used for imaging applications. Crucially, long exposure photostability and device performance were found to be stable over a one hour period (peak pressure variation %), longer than required for standard clinical imaging applications.
全光超声（OpUS）成像已成为一种非常适合微创手术的成像模式。在这种模式下，当脉冲光或调制光被涂层材料吸收时会产生超声。通过设计波长选择性涂层，互补的成像和治疗模式可以与OpUS集成。在此，我们展示了一种由近红外吸收染料和聚二甲基硅氧烷组成的波长选择性复合材料。这种材料的光吸收在1064nm附近达到峰值，高达91%的入射光被吸收，同时在其他波长下保持较低的光吸收。这种材料被用于产生超声，所展示的超声压力为 MPa，与成像应用中使用的压力一致。至关重要的是，发现长时间曝光的光稳定性和设备性能在一小时内保持稳定（峰值压力变化 %），比标准临床成像应用所需的时间更长。
