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用于大容量超声层析成像的激光诱导超声发射器。

Laser-induced ultrasound transmitters for large-volume ultrasound tomography.

作者信息

Thompson D, Nagel J R, Gasteau D B, Manohar S

机构信息

Multimodal Medical Imaging (M3i) group, Technical Medical Centre, University of Twente, Netherlands.

出版信息

Photoacoustics. 2021 Nov 10;25:100312. doi: 10.1016/j.pacs.2021.100312. eCollection 2022 Mar.

Abstract

We present a protocol for the design, fabrication and characterisation of laser-induced ultrasound transmitters with a specific, user-defined frequency response for the purpose of ultrasound tomography of large-volume biomedical samples. Using an analytic solution to the photoacoustic equation and measurements of the optical and acoustic properties of the materials used in the transmitters, we arrive at a required mixture of carbon black and polydimethylsiloxane to achieve the desired frequency response. After an in-depth explanation of the fabrication and characterisation approaches we show the performance of the fabricated transmitter, which has a centre frequency of 0.9 MHz, 200% bandwidth and 45.8 opening angle, multi-kPa pressures over a large depth range in water.

摘要

我们提出了一种用于设计、制造和表征激光诱导超声发射器的方案,该发射器具有特定的、用户定义的频率响应,用于对大容量生物医学样本进行超声层析成像。通过对光声方程的解析解以及对发射器中所用材料的光学和声学特性的测量,我们得出了实现所需频率响应所需的炭黑和聚二甲基硅氧烷的混合物。在深入解释制造和表征方法之后,我们展示了所制造发射器的性能,其中心频率为0.9 MHz,带宽为200%,开口角度为45.8°,在水中的大深度范围内能产生多千帕的压力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070f/8626690/0595d77271bc/gr1.jpg

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