Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.
Molecular Microbiology Laboratory, Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Cell Infect Microbiol. 2022 May 25;12:852900. doi: 10.3389/fcimb.2022.852900. eCollection 2022.
Helminth infections remain a global public health issue, particularly in low- and middle-income countries, where roundworms from the and genera are most prevalent. These geohelminths not only impact human health but most importantly also affect animal well-being, in particular the swine industry. Host-helminth parasite interactions are complex and at the same time essential to understand the biology, dynamics and pathophysiology of these infections. Within these interactions, the immunomodulatory capacity of these helminths in the host has been extensively studied. Moreover, in recent years a growing interest on how helminths interact with the intestinal microbiota of the host has sparked, highlighting how this relationship plays an essential role in the establishment of initial infection, survival and persistence of the parasite, as well as in the development of chronic infections. Identifying the changes generated by these helminths on the composition and structure of the host intestinal microbiota constitutes a field of great scientific interest, since this can provide essential and actionable information for designing effective control and therapeutic strategies. Helminths like and are a focus of special importance due to their high prevalence, higher reinfection rates, resistance to anthelmintic therapy and unavailability of vaccines. Therefore, characterizing interactions between these helminths and the host intestinal microbiota represents an important approach to better understand the nature of this dynamic interface and explore novel therapeutic alternatives based on management of host microbiota. Given the extraordinary impact this may have from a biological, clinical, and epidemiological public health standpoint, this review aims to provide a comprehensive overview of current knowledge and future perspectives examining the parasite-microbiota interplay and its impact on host immunity.
寄生虫感染仍然是一个全球性的公共卫生问题，特别是在低收入和中等收入国家，那里最常见的是 和 属的线虫。这些土源性寄生虫不仅影响人类健康，而且最重要的是还影响动物的福利，特别是养猪业。宿主-寄生虫相互作用非常复杂，同时对于理解这些感染的生物学、动态和病理生理学也至关重要。在这些相互作用中，这些寄生虫在宿主中的免疫调节能力已经得到了广泛的研究。此外，近年来，人们对寄生虫如何与宿主的肠道微生物群相互作用越来越感兴趣，这突显了这种关系在寄生虫初始感染的建立、生存和持续存在以及慢性感染的发展中所起的重要作用。确定这些寄生虫对宿主肠道微生物群的组成和结构产生的变化，是一个具有重要科学意义的领域，因为这可以为设计有效的控制和治疗策略提供重要和可行的信息。 和 等寄生虫因其高流行率、较高的再感染率、对驱虫治疗的耐药性和缺乏疫苗而成为特别重要的研究焦点。因此，描述这些寄生虫与宿主肠道微生物群之间的相互作用，代表了一种更好地理解这种动态界面性质的重要方法，并探索基于宿主微生物群管理的新型治疗替代方案。鉴于从生物学、临床和流行病学公共卫生的角度来看，这可能具有非凡的影响，因此，本综述旨在提供当前知识和未来观点的全面概述，研究寄生虫-微生物群相互作用及其对宿主免疫的影响。
