State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Org Biomol Chem. 2022 Jun 22;20(24):4993-4998. doi: 10.1039/d2ob00697a.
A synthetic protocol based on Cp*Co-catalyzed C-H amidation/annulation of 2-aryl-1-imidazoles with 1,4,2-dioxazol-5-ones was developed to give imidazo[1,2-]quinazoline derivatives with broad substrate scope in moderate to good yields. The method has good prospects of application in the synthesis of imidazo[1,2-]quinazoline drugs.
开发了一种基于 Cp*Co 催化的 2-芳基-1-咪唑与 1,4,2-二恶唑-5-酮的 C-H 酰胺化/环化的合成方案，以中等至良好的收率得到具有广泛底物范围的咪唑并[1,2-a]喹唑啉衍生物。该方法在合成咪唑并[1,2-a]喹唑啉药物方面具有广阔的应用前景。
