以恩诺沙星为基础的衍生物：抗菌和抗生物膜剂：一种面向生物学的药物合成（BIODS）方法。
Enoxacin-based derivatives: antimicrobial and antibiofilm agent: a biology-oriented drug synthesis (BIODS) approach.
机构信息
Dr. Panjwani Center for Molecular Medicine & Drug Research, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
H.E.J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan.
出版信息
Future Med Chem. 2022 Jul;14(13):947-962. doi: 10.4155/fmc-2022-0065. Epub 2022 Jun 13.
To find alternative molecules against , and methicillin-resistant , new enoxacin derivatives were synthesized and screened. All derivatives exhibited promising antibacterial activities as compared to standard enoxacin (2 μg/ml) and standard cefixime (82 μg/ml). Compounds , and significantly downregulated the gene expression of biofilm-forming genes. Based on our results, these molecules may serve as potential drug candidates to cure several bacterial infections in the future.
为了寻找针对 、 和耐甲氧西林的替代分子，我们合成并筛选了新的依诺沙星衍生物。与标准依诺沙星（2μg/ml）和标准头孢克肟（82μg/ml）相比，所有衍生物均表现出有希望的抗菌活性。化合物 、 和 显著下调了生物膜形成基因的基因表达。基于我们的结果，这些分子可能成为未来治疗多种细菌感染的潜在药物候选物。
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