Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan.
Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan.
Chin J Nat Med. 2017 Dec;15(12):944-949. doi: 10.1016/S1875-5364(18)30011-6.
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.
从菝葜中分离得到三个新的烷基取代蒽醌衍生物，分别命名为symploquinones A-C（化合物 1-3）。基于广泛的光谱分析（UV、IR、质谱、H 和 C-NMR 以及二维（2D）NMR 技术）确定了这些化合物的结构。所得数据也与文献报道进行了比较。然后对这些化合物进行了抗菌或抗生物膜测试。化合物 1 和 3 在 160-83 μg·mL 的浓度范围内对变异链球菌、耐甲氧西林金黄色葡萄球菌和奇异变形杆菌表现出良好的抗菌活性。这两种化合物都进一步筛选了抗生物膜活性，在亚 MIC 浓度下显示出有希望的活性。没有一种化合物对肺炎克雷伯菌有活性。
