Dermatology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Medicine and Surgery, School of Medicine, University of Milano-Bicocca, Monza, Italy.
J Med Virol. 2023 Jan;95(1):e27924. doi: 10.1002/jmv.27924. Epub 2022 Jun 20.
The role of human oncoviruses in melanoma has been poorly investigated. The aim of this study was to investigate the association between oncoviruses and melanomas searching for human papillomavirus (HPV), Epstein Barr virus (EBV), and human herpesvirus 8DNA in melanoma specimens. Formalin-fixed and paraffin-embedded tissue specimens of cutaneous, mucosal, and ocular melanomas (OM) were selected from the Pathology Departments of the Galliera Hospital (Genoa) and the University Hospitals of Turin and Cagliari. Cutaneous and mucosal nevi have been collected as controls. The oncoviruses search has been performed with different polymerase chain reaction reagent kits. Fifty-four melanomas (25 mucosal, 12 ocular, and 17 cutaneous) and 26 nevi (15 cutaneous and 11 mucosal) specimens were selected. The detection rate for one of the investigated oncoviruses was 17% in mucosal, 20% in ocular, and 0% in cutaneous melanomas (CMs). Despite the differences between groups seeming remarkable, there was no statistical significance (p > 0.5). Our data do not support a primary role of oncoviruses in melanoma carcinogenesis; however, the finding of HPV and EBV DNA in a considerable fraction of mucosal and OMs suggests that these viruses may act as cofactors in the development of extra-CMs.
人类致癌病毒在黑色素瘤中的作用尚未得到充分研究。本研究旨在探讨致癌病毒与黑色素瘤之间的关联，寻找人乳头瘤病毒（HPV）、Epstein Barr 病毒（EBV）和人类疱疹病毒 8DNA 在黑色素瘤标本中的存在。从热那亚加拉耶拉医院（Genoa）和都灵大学医院和卡利亚里大学医院的病理学系选择了皮肤、黏膜和眼部黑色素瘤（OM）的福尔马林固定和石蜡包埋组织标本。收集了皮肤和黏膜痣作为对照。使用不同的聚合酶链反应试剂试剂盒进行致癌病毒检测。选择了 54 例黑色素瘤（25 例黏膜、12 例眼部和 17 例皮肤）和 26 例痣（15 例皮肤和 11 例黏膜）标本。在所研究的致癌病毒中，有 1 种在黏膜黑色素瘤中的检出率为 17%，在眼部黑色素瘤中的检出率为 20%，在皮肤黑色素瘤（CM）中的检出率为 0%。尽管各组之间的差异似乎很显著，但无统计学意义（p>0.5）。我们的数据不支持致癌病毒在黑色素瘤发生中的主要作用；然而，HPV 和 EBV DNA 在相当一部分黏膜和 OM 中被发现，提示这些病毒可能在 CM 外的发病中起协同作用。
