University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Clin Transplant. 2022 Aug;36(8):e14750. doi: 10.1111/ctr.14750. Epub 2022 Jun 28.
There are nearly 150 living donors in the United States who donated more than one solid organ. Using our divisional database, we found 20 individuals who donated a liver and a kidney at different times. We performed a retrospective chart review of these donors, studying their motivating factors, complications and outcomes. The donors included 11 (55%) males and nine females. Thirteen (65%) donated the kidney before the liver. Fourteen (70%) were nondirected donors at the first donation, and four of the six directed donors in the first donation became nondirected in the second donation. Seventeen (85%) were nondirected at the second donation. Common reasons for donating the second time were a good experience with the first donation and knowing that one can donate again. Outcomes and the incidence of early complications were not significantly different after the 2nd versus the 1st donation. All donors recovered and currently are doing well. Our results show a significant number of dual organ donors are nondirected and motivated by their strong desire to help. A positive experience with the 1st donation often was the driving factor for the 2nd. A history of previous organ donation did not negatively impact the 2nd donation.
美国有近 150 名活体捐献者捐献了超过一种实体器官。我们使用部门数据库，发现有 20 人在不同时间捐献了肝脏和肾脏。我们对这些捐献者进行了回顾性图表审查，研究了他们的动机、并发症和结果。这些捐献者包括 11 名（55%）男性和 9 名女性。13 名（65%）人先捐献了肾脏，然后捐献肝脏。14 名（70%）人在第一次捐献时是非定向捐献者，而在第一次捐献中有 6 名定向捐献者中有 4 名在第二次捐献中变成了非定向捐献者。17 人（85%）在第二次捐献时是非定向捐献者。第二次捐献的常见原因是第一次捐献的良好体验和知道自己可以再次捐献。第二次与第一次相比，结果和早期并发症的发生率没有显著差异。所有捐献者都康复了，目前情况良好。我们的结果表明，相当数量的双器官捐献者是非定向的，他们强烈希望提供帮助。第一次捐献的良好体验往往是第二次捐献的动力。以前有器官捐献史并没有对第二次捐献产生负面影响。
