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早产儿代谢性骨病的危险因素：一项荟萃分析。

Risk factors for metabolic bone disease of prematurity: A meta-analysis.

机构信息

The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.

People's Hospital of Zhengding County, Shijiazhuang, Hebei Province, China.

出版信息

PLoS One. 2022 Jun 13;17(6):e0269180. doi: 10.1371/journal.pone.0269180. eCollection 2022.

DOI:10.1371/journal.pone.0269180
PMID:35696368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9191712/
Abstract

OBJECTIVE

To investigate the risk factors for metabolic bone disease of prematurity (MBDP), and to provide a reference for the prevention of MBDP.

METHODS

The databases including China Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Data, and Weipu Periodical Database, PubMed, Web of Science, Embase, Cochrane Library and other databases were searched for studies on the risk factors for MBDP published up to June 18, 2021. RevMan 5.3 and Stata 14.1 software were used to perform a Meta analysis.

RESULTS

A total of 15 articles were included, including 13 case-control studies, 1 current investigation, and 1 retrospective cohort study. There were 1,435 cases in the case group and 2,057 cases in the control group, with a total sample size of 3,492 cases. Meta analysis showed that risk factors for MBDP include birth weight <1000g (OR = 6.62, 95%CI: 2.28-19.25), gestational age <32 weeks (OR = 2.73, 95%CI: 1.07-6.95), septicemia (OR = 2.53, 95%CI: 1.69-3.79), parenteral nutrition time (OR = 4.04, 95%CI: 1.72-9.49), cholestasis (OR = 3.50, 95%CI: 1.49-8.23), intrauterine growth retardation (OR = 6.89, 95%CI: 3.81-12.44), while the birth weight(OR = 0.44, 95%CI: 0.21-0.90) and gestational age (OR = 0.57, 95%CI: 0.44-0.73)are the protective factors of MBDP.

CONCLUSION

Factors like birth weight <1000g, gestational age <32 weeks, septicemia, parenteral nutrition time, cholestasis, and intrauterine growth retardation may increase the risk of metabolic bone disease of prematurity.

摘要

目的

探讨早产儿代谢性骨病（MBDP）的危险因素，为 MBDP 的防治提供参考。

方法

检索中国生物医学文献服务系统、中国知网、万方数据、维普期刊数据库、PubMed、Web of Science、Embase、Cochrane 图书馆等数据库，查找 2021 年 6 月 18 日前发表的关于 MBDP 危险因素的研究。采用 RevMan 5.3 和 Stata 14.1 软件进行 Meta 分析。

结果

共纳入 15 篇文献，包括 13 项病例对照研究、1 项现况调查和 1 项回顾性队列研究，病例组 1435 例，对照组 2057 例，总样本量 3492 例。Meta 分析结果显示，MBDP 的危险因素包括出生体重<1000g（OR=6.62，95%CI：2.2819.25）、胎龄<32 周（OR=2.73，95%CI：1.076.95）、败血症（OR=2.53，95%CI：1.693.79）、肠外营养时间（OR=4.04，95%CI：1.729.49）、胆汁淤积（OR=3.50，95%CI：1.498.23）、宫内生长迟缓（OR=6.89，95%CI：3.8112.44），而出生体重（OR=0.44，95%CI：0.210.90）和胎龄（OR=0.57，95%CI：0.440.73）是 MBDP 的保护因素。

结论

出生体重<1000g、胎龄<32 周、败血症、肠外营养时间、胆汁淤积和宫内生长迟缓等因素可能增加早产儿代谢性骨病的发病风险。

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