McDonald A R, Maddux B A, Okabayashi Y, Wong K Y, Hawley D M, Logsdon C D, Goldfine I D
Diabetes. 1987 Jun;36(6):779-81. doi: 10.2337/diab.36.6.779.
We found with IM-9 human cultured lymphocytes, that the glucocorticoid dexamethasone increased insulin-receptor mRNA levels. This increase correlated in a time- and dose-dependent manner with the increase in the biosynthesis of the insulin-receptor precursor. In addition, in AR42J cultured rat pancreatic acinar cells, dexamethasone increased insulin-receptor mRNA levels. These studies suggest, therefore, that an increase in mRNA levels is an early step in the regulation of the insulin receptor by glucocorticoids in several cell types.
我们发现，对于IM-9人培养淋巴细胞，糖皮质激素地塞米松可提高胰岛素受体mRNA水平。这种增加与胰岛素受体前体生物合成的增加呈时间和剂量依赖性相关。此外，在AR42J培养的大鼠胰腺腺泡细胞中，地塞米松也提高了胰岛素受体mRNA水平。因此，这些研究表明，mRNA水平的增加是糖皮质激素在多种细胞类型中调节胰岛素受体的早期步骤。
