Bent-Hansen L, Feldt-Rasmussen B, Kverneland A, Deckert T
Diabetologia. 1987 Jan;30(1):2-4. doi: 10.1007/BF01788898.
The transcapillary escape rate and relative plasma disappearance of glycated and non-glycated albumin were measured in 25 male Type 1 (insulin-dependent) diabetic patients using a double tracer technique. The patients were divided into three groups on the basis of their urinary albumin excretion: group 1, normal albumin excretion (less than 30 mg/24 h) (n = 8); group 2, microalbuminuria (30-300 mg/24 h) (n = 9); and group 3, clinical nephropathy (greater than 300 mg/24 h) (n = 8). Six male age-matched non-diabetic persons served as control subjects. The transcapillary escape rate of glycated albumin was similar in group 1 and control subjects (4.7 +/- 2.1 versus 5.1 +/- 1.7%), but significantly increased in group 2 (7.0 +/- 1.7%, p less than 0.05) and in group 3 (7.9 +/- 3.1%, p less than 0.05). The transcapillary escape rate of glycated albumin was slightly lower than that of non-glycated albumin in all groups, but significant only in normal control subjects. No difference in the catabolic rate of glycated and non-glycated albumin was found. We conclude that the in vivo effects of glycation on the clearance and transcapillary passage of albumin are small and not likely to play any significant role in the development of late diabetic microvascular complications.
采用双示踪技术对25例1型（胰岛素依赖型）男性糖尿病患者糖化白蛋白和非糖化白蛋白的毛细血管逃逸率及相对血浆消失率进行了测定。根据尿白蛋白排泄情况将患者分为三组：第1组，正常白蛋白排泄（小于30mg/24h）（n = 8）；第2组，微量白蛋白尿（30 - 300mg/24h）（n = 9）；第3组，临床肾病（大于300mg/24h）（n = 8）。6名年龄匹配的男性非糖尿病患者作为对照。第1组糖化白蛋白的毛细血管逃逸率与对照相似（4.7±2.1%对5.1±1.7%），但在第2组（7.0±1.7%，p＜0.05）和第3组（7.9±3.1%，p＜0.05）显著升高。所有组中糖化白蛋白的毛细血管逃逸率均略低于非糖化白蛋白，但仅在正常对照中差异显著。未发现糖化白蛋白和非糖化白蛋白分解代谢率有差异。我们得出结论，糖化对白蛋白清除和毛细血管通透性的体内影响较小，不太可能在糖尿病晚期微血管并发症的发生中起任何重要作用。
