Department of Psychology, University of Nebraska-Lincoln, United States; Center for Brain, Biology & Behavior, University of Nebraska-Lincoln, United States.
Department of Psychological and Brain Sciences, Indiana University, United States.
Brain Behav Immun. 2022 Aug;104:171-180. doi: 10.1016/j.bbi.2022.06.005. Epub 2022 Jun 10.
To examine the influence of sexual arousal on vaginal mucosal inflammatory cytokine and antibody production in healthy women with and without histories of childhood and/or adult sexual violence.
Ninety-one premenopausal healthy women (ages 18-42) attended a single laboratory session in which they provided vaginal fluid samples before and after viewing one neutral and one erotic film. While viewing the films, participants' vaginal sexual arousal was recorded using vaginal photoplethysmography.
Of the 91 participants, 41 (45%) reported no history of sexual violence, 17 (19%) reported a history of childhood sexual abuse (CSA) only, 19 (21%) reported a history of adult sexual assault (ASA) only, and 10 (11%) reported a history of both CSA and ASA, with 4 participants choosing not to provide information on their sexual violence history. For women with a history of ASA but not CSA, there was a significant increase in vaginal IL-1β following arousal, while for women with a history of CSA (with or without ASA), there was a significant decrease. Women without CSA histories had a significant increase in vaginal IgA following sexual arousal, while women with CSA histories had a decrease.
Sexual arousal possibly plays a role in modifying vaginal immune responses in young, healthy women. Moreover, these effects may vary depending upon sexual assault histories, such that relative to women without assault histories, women with a history of early life sexual trauma showed significantly altered vaginal immune responses following sexual arousal. If replicated, these findings may help explain the increased risk for sexually transmitted infections observed among women with sexual assault histories.
探讨性唤起对有和无儿童期和/或成年期性暴力史的健康女性阴道黏膜炎症细胞因子和抗体产生的影响。
91 名绝经前健康女性（年龄 18-42 岁）参加了一次单实验室会议，在观看中性和色情电影前后提供阴道液样本。在观看电影时，使用阴道光体积描记法记录参与者的阴道性唤起。
在 91 名参与者中，41 名（45%）报告无性暴力史，17 名（19%）报告仅儿童期性虐待（CSA）史，19 名（21%）报告仅成年性攻击（ASA）史，10 名（11%）报告 CSA 和 ASA 均有，4 名参与者选择不提供性暴力史信息。对于有 ASA 但无 CSA 史的女性，性唤起后阴道 IL-1β 显著增加，而对于有 CSA（无论是否有 ASA）史的女性，阴道 IL-1β 显著减少。无 CSA 史的女性性唤起后阴道 IgA 显著增加，而有 CSA 史的女性则减少。
性唤起可能在调节年轻健康女性的阴道免疫反应中发挥作用。此外，这些影响可能因性攻击史而异，与无攻击史的女性相比，有早期性创伤史的女性在性唤起后阴道免疫反应明显改变。如果得到复制，这些发现可能有助于解释在有性攻击史的女性中观察到的性传播感染风险增加。
