Servicio de Dermatología. Hospital Universitario San Cecilio. Departamento de Eczema de Contacto e Inmunoalergia, Granada, España.
Dermatología, Hospital Universitario San Cecilio, Granada, España.
Actas Dermosifiliogr. 2022 May;113(5):498-504. doi: 10.1016/j.ad.2021.12.015. Epub 2022 Jan 31.
Hydrochlorothiazide and other thiazide diuretics have been used for decades to treat high blood pressure, heart failure, and chronic kidney disease. Thiazides have been linked to photosensitivity with heterogeneous clinical manifestations and recovery times. Diagnosis can be aided by phototesting, photopatch testing, and skin biopsy. Long-term use of hydrochlorothiazide has been linked to an increased dose-dependent risk of certain types of skin cancer in recent years. In this review, we also look at other less common or lesser-known adverse effects of thiazide diuretics that have been described in isolated reports.
氢氯噻嗪和其他噻嗪类利尿剂已被使用数十年，用于治疗高血压、心力衰竭和慢性肾脏病。噻嗪类药物与光敏感性有关，具有不同的临床表现和恢复时间。光测试、光斑贴试验和皮肤活检有助于诊断。近年来，长期使用氢氯噻嗪与某些类型皮肤癌的剂量依赖性风险增加有关。在这篇综述中，我们还研究了噻嗪类利尿剂在孤立报道中描述的其他不太常见或不太为人知的不良反应。
