Department of Biochemistry, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka
Department of Biochemistry, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
BMJ Open. 2022 Jun 13;12(6):e057808. doi: 10.1136/bmjopen-2021-057808.
Pathogenesis of gallstones (GS) is multifactorial and is influenced by numerous environmental and genetic risk factors. As a result, clinico-epidemiology and aetiopathogenesis of GS vary in different populations. Understanding the aetiopathogenesis of GS for different populations is imperative in control and prevention of GS disease and its associated complications. This protocol describes the methodology of a scoping review which focuses on synthesising the most updated knowledge on GS disease in South Asia.
The scoping review proposed in this protocol will be guided by Arksey and O'Malley's framework and the Joanna Briggs Institute Reviewers' Manual. Accordingly, population, concept and context strategy will be used to formulate the scoping review question, eligibility criteria and search strategy. In the search, electronic databases, MEDLINE/PubMed, ScienceDirect, Scopus, Cochrane library, CINAHL, Trip, and Google scholar, as well as various grey literature sources will be used in synthesising and presenting the findings on clinico-epidemiology and aetiopathogenesis of GS disease in South Asia.
As secondary data will be used in the study, ethical approval will not be required. The scoping review proposed by this protocol will accurately summarise the current knowledge on GS disease in South Asia based on published and unpublished literature on the field. Thus, the evidence presented in the review will be important for healthcare providers to make decisions on the control and prevention of GS disease and as well as to identify future research priorities on GS disease in South Asia.
胆结石（GS）的发病机制是多因素的，受许多环境和遗传风险因素的影响。因此，GS 在不同人群中的临床流行病学和病因发病机制也有所不同。了解不同人群 GS 的病因发病机制对于 GS 疾病及其相关并发症的控制和预防至关重要。本方案描述了一项范围综述的方法学，该综述侧重于综合南亚 GS 疾病的最新知识。
本方案中提出的范围综述将遵循 Arksey 和 O'Malley 的框架以及 Joanna Briggs 研究所评论员手册。因此，将使用人群、概念和背景策略来制定范围综述问题、资格标准和搜索策略。在搜索中，将使用电子数据库、MEDLINE/PubMed、ScienceDirect、Scopus、Cochrane 图书馆、CINAHL、Trip 和 Google Scholar 以及各种灰色文献来源，综合并呈现南亚 GS 疾病的临床流行病学和病因发病机制方面的发现。
由于本研究将使用二次数据，因此不需要伦理批准。本方案提出的范围综述将根据该领域已发表和未发表的文献，准确总结南亚 GS 疾病的现有知识。因此，该综述中提出的证据对于医疗保健提供者在 GS 疾病的控制和预防方面做出决策以及确定南亚 GS 疾病的未来研究重点非常重要。
