National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.
National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia
BMJ Open. 2022 Jun 13;12(6):e060312. doi: 10.1136/bmjopen-2021-060312.
Idiopathic inflammatory myopathies (IIM). described as 'inflammatory myositis', are a heterogeneous group of rare muscular autoimmune diseases characterised by skeletal muscle inflammation. Its complex characteristics with lack of accurate diagnostic tests, unified classification system and comprehensive widely used diagnostic criteria could lead to diagnostic delay. This study will review diagnostic delay in myositis and provide an overview and clearer insight of patients' experiences, causes and consequences of diagnostic delay in myositis.
The literature source will be a systematic search of PubMed/MEDLINE, Scopus, ProQuest and sources of grey literature, conducted from database inception to December 2021 without restrictions on publication date. All study types (qualitative and quantitative) except review articles, examining diagnostic delay, incorrect diagnosis, missed diagnosis or slow diagnosis of all types of myositis in all ages will be included. Evidence of patients' experiences associated with diagnostic delay will also be examined. Studies in languages other than English, German and Indonesian will be excluded. Outcomes will be diagnostic delay time, patients' experiences, and causes and consequences associated with diagnostic delay in myositis. Two review authors will independently screen the titles and abstracts of search results against the inclusion criteria. The Mixed Methods Appraisal Tool (MMAT) will be used to appraise selected studies. Two independent authors will extract data using a prepiloted data extraction tool. If sufficient quantitative data is available, a meta-analysis will be conducted along with subgroup analysis including pooled diagnostic delay in each type of myositis. Qualitative data will be analysed in line with meta-aggregation methods. If data is insufficient, a narrative synthesis will be conducted.
As this work is a systematic review, ethical approval was not required. Findings of the study will be disseminated through publications in peer-reviewed journals, conferences and symposia.
CRD42022289830.
特发性炎性肌病（IIM）。被描述为“炎性肌病”，是一组罕见的肌肉自身免疫性疾病，其特征为骨骼肌炎症。由于缺乏准确的诊断测试、统一的分类系统和全面广泛使用的诊断标准，其复杂特征可能导致诊断延迟。本研究将回顾肌炎的诊断延迟，并提供肌炎患者的诊断延迟经历、原因和后果的概述和更清晰的认识。
文献来源将是对 PubMed/MEDLINE、Scopus、ProQuest 和灰色文献来源的系统搜索，从数据库创建开始到 2021 年 12 月进行，不限制出版日期。所有研究类型（定性和定量），除了审查文章，检查所有类型和所有年龄段的肌炎的诊断延迟、错误诊断、漏诊或诊断缓慢都将包括在内。还将检查与诊断延迟相关的患者经验的证据。将排除语言不是英语、德语和印度尼西亚语的研究。结果将是诊断延迟时间、患者的经验以及与肌炎的诊断延迟相关的原因和后果。两名综述作者将独立筛选标题和摘要，以确定是否符合纳入标准。将使用混合方法评估工具（MMAT）评估选定的研究。两名独立作者将使用预编程的数据提取工具提取数据。如果有足够的定量数据，将进行荟萃分析，并进行亚组分析，包括每种肌炎的汇总诊断延迟。定性数据将根据元聚合方法进行分析。如果数据不足，将进行叙述性综合。
由于这项工作是系统评价，因此不需要伦理批准。研究结果将通过在同行评议期刊、会议和研讨会上发表来传播。
PROSPERO 注册号：CRD42022289830。
