University of California, Davis Eye Center, Sacramento, USA.
Sci Rep. 2022 Jun 13;12(1):9763. doi: 10.1038/s41598-022-13106-3.
Investigators have reported reduced visibility of the cone photoreceptors overlying drusen using adaptive optics (AO) imaging techniques. Two hypotheses have been proposed to explain this phenomenon. First, the disease-related deformation of the photoreceptor outer segment (OS) may reduce its ability to act as a wave guide, thus decreasing the cell's familiar reflectance pattern. Second, drusen could disorient the photoreceptors away from the eye's pupil, reducing the amount of light reflected back out the pupil. In this work, we use directional OCT (dOCT) images of drusen in AMD patients to measure the respective contributions of these deforming and disorienting factors.
研究人员使用自适应光学（AO）成像技术报告了在玻璃膜疣上的锥状光感受器的可见度降低。有两种假说被提出来解释这种现象。第一种，与疾病相关的光感受器外节（OS）变形可能会降低其作为波导的能力，从而减少细胞熟悉的反射模式。第二种，玻璃膜疣可能会使光感受器偏离眼睛的瞳孔，从而减少反射回瞳孔的光量。在这项工作中，我们使用 AMD 患者的玻璃膜疣的定向 OCT（dOCT）图像来测量这些变形和定向因素的各自贡献。
