住院的 SARS-CoV-2 Alpha 变异株感染患者发生重症 COVID-19 的风险增加：一项多中心匹配队列研究。
Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study.
机构信息
Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), INSERM UMR1291, CNRS UMR5051, Université Toulouse III, Toulouse, France.
出版信息
BMC Infect Dis. 2022 Jun 13;22(1):540. doi: 10.1186/s12879-022-07508-x.
BACKGROUND
The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France.
METHODS
We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease.
RESULTS
We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]).
CONCLUSION
Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.
背景
变异新冠病毒（VOC）Alpha 对 COVID-19 严重程度的影响一直存在争议。我们报告了在法国的分析结果。
方法
我们进行了一项回顾性数据收集的暴露/未暴露队列研究，比较了感染 VOC Alpha 的患者与同期感染历史谱系的患者。参与者按照年龄（±2.5 岁）、性别和住院地区进行匹配。主要终点是严重 COVID-19 的住院患者比例，定义为世界卫生组织（WHO）量表>5 或需要非再呼吸面罩，发生在入院后 29 天内。我们使用了一个逻辑回归模型，对每个匹配对进行分层，并考虑了已知与疾病严重程度相关的因素。
结果
我们纳入了 2021 年 1 月 1 日至 2 月 28 日期间在 47 家医院住院的 650 对患者。中位年龄为 70 岁，61.3%的参与者为男性。两组的合并症比例都很高（85.0% vs 90%，p=0.004）。感染 VOC Alpha 与严重 COVID-19 的可能性更高相关（41.7% vs 38.5%-优势比[OR]1.33，95%置信区间[CI]1.03-1.72）。
结论
感染 VOC Alpha 与严重 COVID-19 的可能性更高相关。
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