Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Department Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Lipids Health Dis. 2022 Jun 13;21(1):53. doi: 10.1186/s12944-022-01664-4.
An excessive rise in maternal lipids during pregnancy may have detrimental impacts on maternal and fetal health leading to adverse pregnancy outcomes. However, knowledge gaps exist with respect to the association between lipid biomarkers and birth outcomes.
We conducted a secondary data analysis of healthy pregnant women (N = 25) with mid-pregnancy fasting serum samples collected at 22-28 weeks of gestation and birth outcome data. Serum was analyzed for conventional lipid profile (total-C, HDL-C, LDL-C, and triglycerides) and lipoprotein subclass distribution, including particle number (nM) and size (nm), for very low-density lipoprotein (VLDL)/chylomicron (CM), low density lipoprotein (LDL), and high-density lipoprotein (HDL), by nuclear magnetic resonance spectroscopy. Associations between maternal lipids and birth outcomes, including birth weight (g) and gestational age (weeks), were assessed using multivariable linear regression, adjusted for pre-pregnancy BMI.
Although conventional lipids were not associated (p > 0.05) with birth outcomes, every 1-unit increment in large VLDL/CM particles (nM) and VLDL/CM size (nm) was associated with an increase in birth weight (confounder-adjusted β-coefficient, 45.80 g [5.30, 86.20, p = 0.003] and 24.90 g [8.80, 40.90, p = 0.002], respectively). Among the HDL subclass parameters, a 1-unit (nM) increase in the concentration of total HDL-particles was associated with a reduced birth weight (confounder adjusted β-coefficient, -19.40 g [95% confidence interval, -36.70, -2.20]; p = 0.03) after adjustment for maternal pre-pregnancy BMI.
The preliminary results of this pilot study suggest that total particle concentrations of VLDL/CM and HDL in mid-pregnancy have divergent associations with birth weight, potentially reflecting the specific roles of these lipoprotein particles with respect to placental function and fetal growth.
孕妇在怀孕期间血脂过度升高可能对母婴健康产生不利影响，导致不良妊娠结局。然而，脂质生物标志物与出生结局之间的关联尚存在知识空白。
我们对 25 名健康孕妇进行了二次数据分析，这些孕妇在妊娠 22-28 周时采集了空腹血清样本，并收集了出生结局数据。采用核磁共振光谱法检测血清中常规脂质谱（总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯）和脂蛋白亚类分布，包括极低密度脂蛋白/乳糜微粒（VLDL/CM）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）的颗粒数（nM）和粒径（nm）。采用多变量线性回归评估母体脂质与出生结局（出生体重（g）和胎龄（周））之间的关系，调整了孕前 BMI。
尽管常规脂质与出生结局无相关性（p＞0.05），但每增加 1 个单位的大 VLDL/CM 颗粒（nM）和 VLDL/CM 粒径（nm），出生体重就会增加（校正混杂因素后的β系数，分别为 45.80g[5.30，86.20]和 24.90g[8.80，40.90]，p=0.003）。在 HDL 亚类参数中，总 HDL 颗粒浓度增加 1 个单位（nM）与出生体重降低相关（校正混杂因素后的β系数，-19.40g[95%置信区间，-36.70，-2.20]；p=0.03）。
这项初步研究结果表明，妊娠中期 VLDL/CM 和 HDL 的总颗粒浓度与出生体重呈不同的关联，这可能反映了这些脂蛋白颗粒对胎盘功能和胎儿生长的特定作用。
