Milanés M V, Martínez J A, Vargas M L
Department of Physiology and Pharmacology, Faculty of Medicine, Murcia, Spain.
J Pharm Pharmacol. 1989 Sep;41(9):607-11. doi: 10.1111/j.2042-7158.1989.tb06540.x.
Neuroleptic drugs increase the biosynthesis and release of opioid peptides from the myenteric plexus of guinea-pig ileum. In the present work, the involvement of dopamine receptors or alpha-adrenoceptors in the release of opioids from the myenteric plexus of guinea-pig was investigated. Acute or chronic treatment with prazosin, an alpha 1-blocking drug, produced no changes in the release of these peptides. Release was also unchanged after acute or chronic treatment with the alpha 2-blocking drug yohimbine. However, treatment with domperidone, a selective dopamine receptor antagonist, resulted in an increase in the release of opioids, as did treatment with (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine ((-)-3-PPP), a dopamine autoreceptor stimulant. It is concluded that the effect of neuroleptics on the release of opioids from myenteric plexus is due to the blockade of dopamine receptors, and that interruption of dopaminergic transmission produces an increase in opioid release at this level.
抗精神病药物可增加豚鼠回肠肌间神经丛中阿片肽的生物合成与释放。在本研究中，对多巴胺受体或α-肾上腺素能受体在豚鼠肌间神经丛阿片类物质释放中的作用进行了研究。用α1阻断药哌唑嗪进行急性或慢性处理，这些肽的释放未发生变化。用α2阻断药育亨宾进行急性或慢性处理后，释放也未改变。然而，用选择性多巴胺受体拮抗剂多潘立酮处理导致阿片类物质释放增加，用多巴胺自身受体激动剂(-)-3-(3-羟苯基)-N-正丙基哌啶((-)-3-PPP)处理也有同样效果。结论是，抗精神病药物对肌间神经丛阿片类物质释放的作用是由于多巴胺受体的阻断，并且多巴胺能传递的中断在此水平上会导致阿片类物质释放增加。
