Division of Reproductive Biology, Maternal & Child Health, Department of Health Research, ICMR, MOHFW, Government of India, Ansari Nagar, New Delhi 110029, India.
Department of Biochemistry, College of Medicine, University of Hail, Hail, KSA‑2240, Saudi Arabia.
Oncol Rep. 2022 Jul;48(1). doi: 10.3892/or.2022.8346. Epub 2022 Jun 14.
Cancer is recognized as the leading cause of death worldwide. The hippo signaling pathway regulates organ size by balancing cell proliferation and cell death; hence dysregulation of the hippo pathway promotes cancer‑like conditions. miRNAs are a type of non‑coding RNA that have been shown to regulate gene expression. miRNA levels are altered in various classes of cancer. Researchers have also uncovered a crosslinking between miRNAs and the hippo pathway, which has been linked to cancer. The components of the hippo pathway regulate miRNA synthesis, and various miRNAs regulate the components of the hippo pathway both positively and negatively, which can lead to cancer‑like conditions. In the present review article, the mechanism behind the hippo signaling pathway and miRNAs biogenesis and crosslinks between miRNAs and the hippo pathway, which result in cancer, shall be discussed. Furthermore, the article will cover miRNA‑related therapeutics and provide an overview of the development of resistance to anticancer drugs. Understanding the underlying processes would improve the chances of developing effective cancer treatment therapies.
癌症被公认为全球主要死亡原因。 Hippo 信号通路通过平衡细胞增殖和细胞死亡来调节器官大小；因此，Hippo 通路的失调会促进类似癌症的状况。miRNA 是一种非编码 RNA，已被证明可以调节基因表达。各种类型的癌症中 miRNA 水平都会发生改变。研究人员还发现了 miRNA 和 Hippo 通路之间的交联，这与癌症有关。Hippo 通路的组成部分调节 miRNA 的合成，而各种 miRNA 则正、负调节 Hippo 通路的组成部分，从而导致类似癌症的状况。在本综述文章中，将讨论 Hippo 信号通路和 miRNA 生物发生的机制以及 miRNA 和 Hippo 通路之间的交联，这些交联会导致癌症，还将讨论 miRNA 相关治疗方法，并概述对抗癌药物产生耐药性的发展。了解潜在的过程将提高开发有效癌症治疗方法的机会。
