Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Biotechnology Research Center, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Biotechnology Research Center, Tabriz Branch, Islamic Azad University, Tabriz, Iran; Department of Basic Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Pathol Res Pract. 2020 Dec;216(12):153241. doi: 10.1016/j.prp.2020.153241. Epub 2020 Oct 9.
Cancer is the major cause of death worldwide in countries of all income levels. The Hippo signaling pathway is a Drosophila kinase gene that was identified to regulate organ size, cell regeneration, and contribute to tumorigenesis. A huge variety of extrinsic and intrinsic signals regulate the Hippo signaling pathway. The Hippo signaling pathway consists of a wide array of components that merge numerous signals such as mechanical signals to address apoptosis resistance, cell proliferation, cellular outputs of growth, cell death and survival at cellular and tissue level. Recent studies have shed new light on the regulatory role of microRNAs in Hippo signaling and how they contribute to cancer progression. MicroRNAs influence various cancer-related processes such as, apoptosis, proliferation, migration, cell cycle and metabolism. Inhibition and overexpression of miRNAs via miRNA mimics and miRNA inhibitors, respectively, can uncover a hopeful and reliable insight for treatment and early diagnosis of cancer patients. In this review we will discuss our current understanding of regulatory role of miRNAs in Hippo signaling pathway.
癌症是全球所有收入水平国家的主要死亡原因。Hippo 信号通路是一种果蝇激酶基因，它被确定可以调节器官大小、细胞再生，并有助于肿瘤发生。大量的外在和内在信号调节 Hippo 信号通路。Hippo 信号通路由一系列广泛的成分组成，这些成分融合了许多信号，如机械信号，以解决抗凋亡、细胞增殖、细胞生长的细胞输出、细胞死亡和存活在细胞和组织水平。最近的研究揭示了 microRNAs 在 Hippo 信号中的调控作用，以及它们如何促进癌症的进展。microRNAs 影响各种与癌症相关的过程，如细胞凋亡、增殖、迁移、细胞周期和代谢。通过 microRNA 模拟物和 microRNA 抑制剂分别抑制和过表达 microRNAs，可以为癌症患者的治疗和早期诊断提供有希望和可靠的见解。在这篇综述中，我们将讨论我们对 microRNAs 在 Hippo 信号通路中的调控作用的理解。
