基于阴离子水溶性[2]联苯扩展柱芳烃的智能超分子纳米药物用于联合治疗。
Intelligent Supramolecular Nanoprodrug Based on Anionic Water-Soluble [2]Biphenyl-Extended-Pillar[6]arenes for Combination Therapy.
机构信息
School of Chemistry and Chemical Engineering, Nantong University, Nantong, 226019, People's Republic of China.
出版信息
ACS Macro Lett. 2022 Jul 19;11(7):830-834. doi: 10.1021/acsmacrolett.2c00322. Epub 2022 Jun 14.
An anionic water-soluble [2]biphenyl-extended-pillar[6]arenes modified with eight ammonium salt ions (AWBpP6) was successfully synthesized to establish a drug-drug conjugate supramolecular nanoprodrug (SNP) with a high drug-loading capacity. This SNP can generate a synergistic triple therapeutic effect of photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT; i.e., PDT-PTT-CT) with excellent biocompatibility.
一种阴离子水溶性[2]联苯扩展柱[6]芳烃，用八个铵盐离子修饰（AWBpP6），成功合成了一种具有高载药能力的药物-药物偶联超分子纳米前药（SNP）。该 SNP 可以产生光动力疗法（PDT）、光热疗法（PTT）和化学疗法（CT）的协同三重治疗效果，具有优异的生物相容性。
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