基于[2]联苯扩展柱[6]芳烃的含一氧化氮的超分子多肽纳米医学用于逆转耐药性。
Nitric oxide-containing supramolecular polypeptide nanomedicine based on [2]biphenyl-extended-pillar[6]arenes for drug resistance reversal.
机构信息
School of Chemistry and Chemical Engineering, Nantong University, Nantong, 226019, P. R. China.
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
出版信息
J Mater Chem B. 2022 Aug 17;10(32):6181-6186. doi: 10.1039/d2tb01127a.
A kind of supramolecular polypeptide nanomedicine (BPC/DOX-ICG) was constructed with an anionic water-soluble [2]biphenyl-extended-pillar[6]arene (AWBpP6), and pyridinium-terminal- and -nitrosothiol (SNO)-modified polypeptide (PPNC) host-guest interactions to co-deliver doxorubicin (DOX) and indocyanine green (ICG) for drug resistance reversal. Upon near-infrared (NIR) irradiation, the NO generation could down-regulate the P-glycoprotein (P-gp) expression level to reverse multidrug resistance (MDR). Subsequently, the resulting reverse MDR could sensitize the free DOX and assist photothermal therapy (PTT) to enhance the tumoricidal potential. This supramolecular polypeptide nanomedicine provides an effective strategy for the multimodal synergistic therapies of photothermal therapy, NO generation therapy, and chemotherapy (, PTT-NO-CT) to overcome MDR.
构建了一种超分子多肽纳米药物（BPC/DOX-ICG），该纳米药物由带负电荷的水溶性[2]联苯扩展柱[6]芳烃（AWBpP6）和吡啶端和硫代亚硝酰基（SNO）修饰的多肽（PPNC）主客体相互作用共同递送多柔比星（DOX）和吲哚菁绿（ICG）以逆转耐药性。近红外（NIR）照射下，NO 的产生可以下调 P-糖蛋白（P-gp）的表达水平，从而逆转多药耐药（MDR）。随后，逆转的多药耐药性可以使游离的 DOX 更加敏感，并辅助光热治疗（PTT）以增强杀伤肿瘤的潜力。这种超分子多肽纳米药物为光热治疗、NO 生成治疗和化疗的多模式协同治疗（PTT-NO-CT）提供了一种有效的策略，以克服 MDR。
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