Division of Biology and Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
J Cutan Pathol. 2022 Oct;49(10):881-884. doi: 10.1111/cup.14273. Epub 2022 Jul 5.
Basaloid follicular hamartomas (BFHs) are rare, benign, cutaneous adnexal tumors characterized by branching cords and anastomosing strands of basaloid cells in a loose, fibrous stroma. BFHs exhibit variable clinical presentations although they are commonly observed as skin-colored papules and are diagnosed based on histopathological features. Common systemic diseases associated with BFH include alopecia, myasthenia gravis, and palmoplantar pitting. BFH of the eyelid is extremely rare with only five cases reported in the literature to date. Congenital "kissing" lesions have only previously been reported with nevi. Here, we present a novel case of congenital "kissing" BFH of the right upper and right lower eyelid, and histopathological examination revealed intradermal nodules of basaloid cells forming reticulated strands, pseudohorn cysts, mucinous stroma, and palisading with CD34 and Bcl-2 expression in the stromal fibroblasts and periphery, respectively.
基底细胞样滤泡性错构瘤（BFHs）是一种罕见的良性皮肤附属器肿瘤，其特征为在疏松的纤维基质中存在分支状条索和吻合的基底样细胞。BFHs 的临床表现具有变异性，尽管它们通常表现为肤色丘疹，但可基于组织病理学特征进行诊断。与 BFH 相关的常见系统性疾病包括脱发、重症肌无力和掌跖凹陷。眼睑 BFH 极为罕见，迄今为止文献中仅报道了 5 例。先天性“亲吻”病变以前仅与痣有关。在此，我们报告了一例右侧上、下眼睑先天性“亲吻”型 BFH 的新病例，组织病理学检查显示真皮内的基底样细胞结节形成网状条索、假角囊肿、黏液基质和沿 CD34 和 Bcl-2 表达的栅栏状排列，分别位于基质成纤维细胞和周围。
