Department of Neurology, Lotung Poh-Ai Hospital, Ilan, Taiwan.
Department of Emergency Medicine, Lotung Poh-Ai Hospital, Ilan, Taiwan.
Hum Vaccin Immunother. 2022 Nov 30;18(5):2082206. doi: 10.1080/21645515.2022.2082206. Epub 2022 Jun 14.
Vaccine-related immune responses are one of the causes of encephalitis. Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) have been administered worldwide due to the ongoing global pandemic; cases of SARS-CoV-2 vaccination-related encephalitis were scarcely reported. An 82-year-old female was diagnosed with acute encephalitis following her first dose of vaccination with mRNA-1273 against SARS-CoV-2. The patient presented with fever and headache five days after vaccination, followed by behavior change 17 days after vaccination. Electroencephalographic recordings revealed focal slow waves in the right frontoparietal regions. Brain MRI revealed the signal change in the right middle and posterior temporal lobe. Cerebrospinal fluid analysis showed mildly elevated protein. She responded well to steroid pulse therapy and made a full recovery. The severity of the immune response following COVID-19 vaccination may be alleviated if adequate treatment is achieved. Physicians must be alert for encephalitis after vaccination to help ensure a favorable outcome.
疫苗相关免疫反应是脑炎的原因之一。由于持续的全球大流行，已在全球范围内接种了针对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2，COVID-19）的疫苗；很少有报道称与 SARS-CoV-2 疫苗接种相关的脑炎病例。一名 82 岁女性在接种 mRNA-1273 疫苗后，出现急性脑炎，这是她接种的第一针 SARS-CoV-2 疫苗。患者在接种疫苗后 5 天出现发热和头痛，接种后 17 天出现行为改变。脑电图记录显示右额顶区局灶性慢波。脑 MRI 显示右中后颞叶信号改变。脑脊液分析显示蛋白轻度升高。她对类固醇冲击治疗反应良好，完全康复。如果及时治疗，COVID-19 疫苗接种后免疫反应的严重程度可能会减轻。医生在接种疫苗后必须警惕脑炎，以帮助确保良好的预后。
