Centro Universitario de Esclerosis Múltiple, CUEM, Facultad de Medicina, Hospital JM Ramos Mejía, Universidad de Buenos Aires, Urquiza 609, CABA, CP, Buenos Aires 1221, Argentina.
CEMIC, Buenos Aires, Argentina; CEMBA, Buenos Aires, Argentina.
Mult Scler Relat Disord. 2022 Jul;63:103915. doi: 10.1016/j.msard.2022.103915. Epub 2022 Jun 1.
Several factors have been associated with poor adherence to disease-modifying drugs (DMD). The aim of this study is to evaluate the adherence to DMD in people with multiple sclerosis (PwMS) in Argentina and Ecuador.
A cross-sectional study was performed. The study was carried out between June 2020 and October 2020, and 303 PwMS treated with DMD were included. Patients undergoing immune reconstitution treatments were excluded. Two definitions of DMD adherence were previously determined. Adherence to MS treatments was assessed using the multiple sclerosis treatment adherence questionnaire (MS-TAQ). The logistic regression model was used to evaluate factors related to adherence, and p < 0.05 was considered significant.
The mean age at study entry for patients was 40.7 ± 11.2 years, 207 (68.3%) were female, and the mean EDSS score was 2.2 ± 1.9. The overall adherence in our sample was 78.1% (79.7% in Argentina and 76% Ecuador, p = 0.23). Patients using infusion therapies significantly more often belonged to the adherent group (p = 0.042). Sharing decision-making (OR = 3.4, 95% CI: 1.7-6.9, p = 0.01), lower EDSS (OR = 0.8, 95% IC: 0.6-0.9, p = 0.004), and lower treatment duration (OR = 0.8, 95% IC: 0.6-0.9, p = 0.001) were independent predictors of adherence in our multivariate model.
We found a prevalence of non-adherence similar to that previously reported. Furthermore, new factors associated with lower adherence were identified.
有几个因素与疾病修饰药物（DMD）的依从性差有关。本研究的目的是评估阿根廷和厄瓜多尔多发性硬化症（PwMS）患者对 DMD 的依从性。
进行了一项横断面研究。该研究于 2020 年 6 月至 2020 年 10 月进行，共纳入 303 名接受 DMD 治疗的 PwMS。排除正在接受免疫重建治疗的患者。先前确定了两种 DMD 依从性的定义。使用多发性硬化症治疗依从性问卷（MS-TAQ）评估 MS 治疗的依从性。使用逻辑回归模型评估与依从性相关的因素，p<0.05 被认为具有统计学意义。
患者入组时的平均年龄为 40.7±11.2 岁，207 名（68.3%）为女性，平均 EDSS 评分为 2.2±1.9。我们样本的总体依从率为 78.1%（阿根廷为 79.7%，厄瓜多尔为 76%，p=0.23）。使用输注疗法的患者更常属于依从组（p=0.042）。共同决策（OR=3.4，95%CI：1.7-6.9，p=0.01）、较低的 EDSS（OR=0.8，95%IC：0.6-0.9，p=0.004）和较短的治疗持续时间（OR=0.8，95%IC：0.6-0.9，p=0.001）是我们多变量模型中依从性的独立预测因素。
我们发现不依从的发生率与之前报道的相似。此外，还确定了与较低依从性相关的新因素。
