Digenis G A, Wells D A, Ansell J M, Blecher L
Food Chem Toxicol. 1987 Mar;25(3):241-3. doi: 10.1016/0278-6915(87)90089-5.
The tissue distribution and excretion of 14C-labelled povidone (polyvinylpyrrolidone; K-30; average mol wt 40,000) was studied in male Sprague-Dawley rats given a single oral dose. The major pathway of elimination of radioactivity was in the faeces, in which 90.8% of the administered dose was recovered after 12 hr and 98.4% after 48 hr. Amounts of radioactivity in major tissues and in the blood were not significantly different from those in untreated controls. A minor amount of radioactivity, representing 0.04% of the administered dose, was detected in the urine after 6 hr. Dialysis studies of [14C]povidone suggested that the absorbed species was a low-molecular-weight (less than 3500) oligomer. It was concluded that an oral dose of [14C]povidone is not significantly absorbed in the rat.
对雄性斯普拉格-道利大鼠单次口服给予14C标记的聚维酮（聚乙烯吡咯烷酮；K-30；平均分子量40,000）后，研究了其组织分布和排泄情况。放射性消除的主要途径是粪便，给药后12小时粪便中回收了90.8%的给药剂量，48小时后回收了98.4%。主要组织和血液中的放射性量与未处理对照相比无显著差异。6小时后在尿液中检测到少量放射性，占给药剂量的0.04%。[14C]聚维酮的透析研究表明，吸收的物质是低分子量（小于3500）的寡聚物。得出的结论是，大鼠口服[14C]聚维酮后吸收不显著。
