Hespe W, Meier A M, Blankwater Y J
Arzneimittelforschung. 1977;27(6):1158-62.
Excretion and autoradiographic distribution studies were performed in rats with two 14C-labelled polyvinylpyrrolidone preparations, both of relatively low mean molecular weight but different in molecular weight distribution. At different time intervals after i.v. administration, elimination of radioactivity was found to be more complete for the preparation with the smallest fraction of molecules having a weight of over 25000, which is approximately the weight limit for rapid glomerular filtration in the rat. Our study demonstrates that the retention of PVP in organs, which in the literature are mentioned as target organs for PVP-toxicity, can be largely prevented by decreasing the fraction of molecules with a weight of more than 25000.
用两种14C标记的聚乙烯吡咯烷酮制剂在大鼠身上进行了排泄和放射自显影分布研究，这两种制剂平均分子量都相对较低，但分子量分布不同。静脉注射给药后不同时间间隔，发现对于分子量超过25000的分子所占比例最小的制剂，放射性消除更完全，25000大约是大鼠肾小球快速滤过的重量极限。我们的研究表明，通过减少分子量超过25000的分子比例，可在很大程度上防止聚乙烯吡咯烷酮在文献中被提及为聚乙烯吡咯烷酮毒性靶器官的器官中的潴留。
