毒蕈碱型胆碱能受体以及组胺能H1和H2受体不参与人体中纳洛酮引起的促黄体激素反应。

Muscarinic cholinergic and histaminergic H1 and H2 receptors are not involved in the LH response to naloxone in man.

作者信息

Chiodera P, Volpi R, Delsignore R, Ippolito L, Rossi G, Camellini L, Marchesi C, Gnudi A, Coiro V

出版信息

Horm Res. 1987;25(2):120-4. doi: 10.1159/000180642.

Abstract

The role of muscarinic-cholinergic and H1-, H2-histaminergic receptors as possible mediators of the LH response to the opioid antagonist naloxone was evaluated in 18 normal men. Subjects were divided in 3 groups of 6 men; the increment of LH in the plasma elicited by naloxone was evaluated after giving naloxone alone or together with dexchlorpheniramine, cimetidine or pirenzepine (respectively H1-, H2-histaminergic and muscarinic-cholinergic receptor antagonists). LH release was significantly stimulated by naloxone in all subjects; this response was not altered by histaminergic or cholinergic blockade. These results confirm the stimulatory effect of naloxone on LH release in man, without evidence of the involvement of H1-, H2-histaminergic or muscarinic-cholinergic pathways.

摘要

在18名正常男性中评估了毒蕈碱型胆碱能受体以及H1、H2组胺能受体作为促黄体生成素（LH）对阿片类拮抗剂纳洛酮反应的可能介导者的作用。受试者被分为3组，每组6人；在单独给予纳洛酮或与右氯苯那敏、西咪替丁或哌仑西平（分别为H1、H2组胺能和毒蕈碱型胆碱能受体拮抗剂）联合给予后，评估纳洛酮引起的血浆中LH的升高。纳洛酮在所有受试者中均显著刺激LH释放；组胺能或胆碱能阻断未改变这种反应。这些结果证实了纳洛酮对人体LH释放的刺激作用，且没有证据表明H1、H2组胺能或毒蕈碱型胆碱能途径参与其中。