Solter M, Tislarić D, Pegan B, Petric V, Sekso M
Horm Res. 1987;25(3):147-51. doi: 10.1159/000180646.
The effect of suppressive treatment with thyroid hormones on thyroidal iodothyronines and T4/T3 ratio in nodular and paranodular tissues was investigated in 12 patients with nontoxic goiter. Results were compared to those from 11 nontreated patients. Continuous thyroid hormone administration produced a significant increase in thyroidal T4 and T4/T3 ratio in nodular tissues while T3 remained unchanged. In paranodular tissues a significant rise of T4/T3 ratio, an insignificant increase in T4 and a decrease in T3 were observed following the administration of thyroid hormones. The results are very similar to those obtained in paranodular tissue of autonomously functioning thyroid nodule, and are probably the consequence of suppressed TSH secretion, as TSH predominantly stimulates the synthesis of T3 and/or thyroidal T4 monodeiodination.
对12例非毒性甲状腺肿患者研究了甲状腺激素抑制治疗对结节及结节旁组织中甲状腺碘甲状腺原氨酸及T4/T3比值的影响。将结果与11例未治疗患者的结果进行比较。持续给予甲状腺激素使结节组织中甲状腺T4及T4/T3比值显著升高，而T3保持不变。给予甲状腺激素后，在结节旁组织中观察到T4/T3比值显著升高、T4轻度升高及T3降低。这些结果与自主功能性甲状腺结节的结节旁组织中所获得的结果非常相似，并且可能是TSH分泌受抑制的结果，因为TSH主要刺激T3的合成及/或甲状腺T4的单碘脱碘作用。
