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癌症患者的胸痛

Chest Pain in the Cancer Patient.

作者信息

Tyebally Sara, Ghose Aruni, Chen Daniel H, Abiodun Aderonke T, Ghosh Arjun K

机构信息

Cardio-Oncology Service, Barts Heart Centre, St Bartholomew's Hospital London, UK.

Oncology Department, St Bartholomew's Hospital London, UK.

出版信息

Eur Cardiol. 2022 May 31;17:e15. doi: 10.15420/ecr.2021.45. eCollection 2022 Feb.

DOI:10.15420/ecr.2021.45
PMID:35702571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9185574/
Abstract

Chest pain is one of the most common presenting symptoms in patients seeking care from a physician. Risk assessment tools and scores have facilitated prompt diagnosis and optimal management in these patients; however, it is unclear as to whether a standardised approach can adequately triage chest pain in cancer patients and survivors. This is of concern because cancer patients are often at an increased risk of cardiovascular mortality and morbidity given the shared risk factors between cancer and cardiovascular disease, compounded by the fact that certain anti-cancer therapies are associated with an increased risk of cardiovascular events that can persist for weeks and even years after treatment. This article describes the underlying mechanisms of the most common causes of chest pain in cancer patients with an emphasis on how their management may differ to that of non-cancer patients with chest pain. It will also highlight the role of the cardio-oncology team, who can aid in identifying cancer therapy-related cardiovascular side-effects and provide optimal multidisciplinary care for these patients.

摘要

胸痛是就医患者最常见的症状之一。风险评估工具和评分有助于对这些患者进行快速诊断和优化管理;然而,尚不清楚标准化方法能否对癌症患者及其幸存者的胸痛进行充分分诊。这令人担忧,因为鉴于癌症与心血管疾病之间存在共同的风险因素,癌症患者的心血管死亡率和发病率往往会增加,此外,某些抗癌治疗与心血管事件风险增加相关,且这种风险在治疗后可能持续数周甚至数年。本文描述了癌症患者胸痛最常见病因的潜在机制,重点强调其管理方式与非癌症胸痛患者的差异。本文还将强调心脏肿瘤学团队的作用,该团队可协助识别与癌症治疗相关的心血管副作用,并为这些患者提供最佳的多学科护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3d8/9185574/5e3141a115a1/ecr-17-e15-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3d8/9185574/5e3141a115a1/ecr-17-e15-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3d8/9185574/5e3141a115a1/ecr-17-e15-g001.jpg

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本文引用的文献

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Cardiac Tumors: State-of-the-Art Review.心脏肿瘤:最新综述
JACC CardioOncol. 2020 Jun 16;2(2):293-311. doi: 10.1016/j.jaccao.2020.05.009. eCollection 2020 Jun.
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CAR T Cell Therapy-Related Cardiovascular Outcomes and Management: Systemic Disease or Direct Cardiotoxicity?嵌合抗原受体T细胞疗法相关的心血管结局与管理:全身性疾病还是直接心脏毒性?
JACC CardioOncol. 2020 Mar 17;2(1):97-109. doi: 10.1016/j.jaccao.2020.02.011. eCollection 2020 Mar.
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The Incidence, Risk Factors, and Outcomes With 5-Fluorouracil-Associated Coronary Vasospasm.
Eur Cardiol. 2023 Feb 16;18:e04. doi: 10.15420/ecr.2022.45. eCollection 2023.
5-氟尿嘧啶相关性冠状动脉痉挛的发病率、危险因素及预后
JACC CardioOncol. 2021 Mar;3(1):101-109. doi: 10.1016/j.jaccao.2020.12.005. Epub 2021 Mar 16.
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Immunotherapy-Associated Cardiotoxicity of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T Cell Therapy: Diagnostic and Management Challenges and Strategies.免疫检查点抑制剂和嵌合抗原受体 T 细胞治疗相关的免疫治疗相关性心脏毒性:诊断和管理挑战及策略。
Curr Cardiol Rep. 2021 Jan 22;23(3):11. doi: 10.1007/s11886-021-01440-3.
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Pericardial Involvement in Cancer.心包累及癌症。
Am J Cardiol. 2021 Apr 15;145:151-159. doi: 10.1016/j.amjcard.2020.12.092. Epub 2021 Jan 15.
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Cardiotoxicity of Contemporary Anticancer Immunotherapy.当代抗癌免疫疗法的心脏毒性
Curr Treat Options Cardiovasc Med. 2020;22(12):62. doi: 10.1007/s11936-020-00867-1. Epub 2020 Nov 3.
7
Radiation-Associated Valvular Disease.放射性瓣膜病。
Curr Cardiol Rep. 2020 Oct 10;22(12):167. doi: 10.1007/s11886-020-01411-0.
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Association between history of cancer and major adverse cardiovascular events in patients with chest pain presenting to the emergency department: a secondary analysis of a prospective cohort study.胸痛患者就诊于急诊科的癌症史与主要不良心血管事件的相关性:一项前瞻性队列研究的二次分析。
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