肥胖与新冠病毒疾病严重程度及死亡率的关联：一项研究的荟萃分析
Association of obesity with COVID-19 diseases severity and mortality: A meta-analysis of studies.
作者信息
Abumweis Suhad, Alrefai Waed, Alzoughool Foad
机构信息
College of Pharmacy, Al Ain University, 64141, Abu Dhabi, United Arab Emirates.
Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, The Hashemite University, P.O. Box 330127, Zarqa, 13133, Jordan.
出版信息
Obes Med. 2022 Aug;33:100431. doi: 10.1016/j.obmed.2022.100431. Epub 2022 Jun 9.
BACKGROUND
The literature on COVID-19 infection is growing every single day, and evidence of presence or absence of association between obesity and COVID-19 adverse outcomes should be revisited. Therefore, this study summarizes the pooled association of obesity with COVID-19 adverse outcomes and mortality.
METHODS
We searched PubMed and Science direct databases using specific terms and defined criteria. Data were analyzed using Comprehensive Meta-Analysis V2 (Biostat, Englewood, NJ, USA)) random-effect models were used to calculate the odds ratio (OR) with 95% confidence intervals (95% CIs) of infection severity and mortality associated with obesity.
RESULTS
Results revealed that obesity is not associated with COVID-19 mortality (OR = 1.1; 95%CI: 0.8 to 1.3) but with other adverse outcomes (OR = 2.4; 95%CI: 1.7 to 3.3).
CONCLUSION
Our findings support previous findings that obesity is associated with COVID-19 severity.
背景
关于新型冠状病毒肺炎（COVID-19）感染的文献每天都在增加，肥胖与COVID-19不良结局之间是否存在关联的证据需要重新审视。因此，本研究总结了肥胖与COVID-19不良结局及死亡率之间的合并关联。
方法
我们使用特定术语和既定标准搜索了PubMed和科学Direct数据库。使用综合Meta分析V2（美国新泽西州恩格尔伍德市Biostat公司）对数据进行分析，采用随机效应模型计算与肥胖相关的感染严重程度和死亡率的比值比（OR）及95%置信区间（95%CI）。
结果
结果显示，肥胖与COVID-19死亡率无关（OR = 1.1；95%CI：0.8至1.3），但与其他不良结局有关（OR = 2.4；95%CI：1.7至3.3）。
结论
我们的研究结果支持了先前的发现，即肥胖与COVID-19的严重程度相关。
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