School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
Qingdao Medical College, Qingdao University, Qingdao, China.
Food Funct. 2022 Jul 4;13(13):6875-6893. doi: 10.1039/d2fo00546h.
The incidence rate of ulcerative colitis (UC) has increased significantly over the past decades and it places an increasing burden on health and social systems. The current studies on UC implicate a strong correlation between host gut microbiota immunity and the pathogenesis of UC. Meanwhile, more and more functional oligosaccharides have been reported as prebiotics to alleviate UC, since many of them can be metabolized by gut microbiota to produce short-chain fatty acids (SCFAs). The present review is focused on the structure, sources and specific applications of various functional oligosaccharides related to the prevention and treatment of UC. The available evidence for the usage of functional oligosaccharides in UC treatment are summarized, including fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), chito-oligosaccharides (COS), alginate-oligosaccharides (AOS), xylooligosaccharides (XOS), stachyose and inulin.
过去几十年来，溃疡性结肠炎（UC）的发病率显著上升，给卫生和社会系统带来了越来越大的负担。目前的 UC 研究表明，宿主肠道微生物群免疫与 UC 的发病机制之间存在很强的相关性。同时，越来越多的功能性低聚糖被报道为可缓解 UC 的益生元，因为它们中的许多可被肠道微生物群代谢生成短链脂肪酸（SCFAs）。本综述重点介绍了与 UC 预防和治疗相关的各种功能性低聚糖的结构、来源和具体应用。总结了功能性低聚糖在 UC 治疗中的应用证据，包括果寡糖（FOS）、半乳寡糖（GOS）、壳寡糖（COS）、藻酸盐寡糖（AOS）、木寡糖（XOS）、棉子糖和菊粉。
