Departments of Obstetrics & Gynecology.
Surgery, Michigan Medicine, University of Michigan Health System, Ann Arbor, Michigan.
Clin Obstet Gynecol. 2022 Sep 1;65(3):510-523. doi: 10.1097/GRF.0000000000000718. Epub 2022 Jun 7.
The use of exogenous estrogen and progesterone/progestin medications spans the reproductive and postreproductive lives of millions of women providing control over pregnancy timing, management of premenopausal and postmenopausal symptoms, and prevention of disease, including endometrial and ovarian cancer. These same hormones can also increase the risk of breast cancer in some settings and their use in breast cancer survivors may increase the risk of breast cancer recurrence. Given both the benefits and risks of these exogenous hormones, a detailed understanding of the available scientific evidence is imperative to help counsel individuals in their use across various settings.
外源性雌激素和孕激素/(progestin)药物的使用贯穿了数百万女性的生殖期和生殖后期，可控制妊娠时机、管理绝经前和绝经后症状，并预防疾病，包括子宫内膜癌和卵巢癌。在某些情况下，这些相同的激素也会增加乳腺癌的风险，而在乳腺癌幸存者中使用这些激素可能会增加乳腺癌复发的风险。鉴于这些外源性激素的益处和风险，详细了解现有科学证据对于帮助个人在各种情况下使用这些激素至关重要。
