Affiliated Stomatological Hospital, Nanchang University, Nanchang, Jiangxi 330006, P. R. China.
Key Laboratory of Oral Biomedicine, Nanchang University, Nanchang, Jiangxi 330006, P. R. China.
ACS Appl Mater Interfaces. 2022 Jun 29;14(25):28427-28438. doi: 10.1021/acsami.2c00887. Epub 2022 Jun 15.
Biofilm-driven caries and tooth discoloration are two major problems in oral health care. The current methods have the disadvantages of insufficient biofilm targeting and irreversible enamel damage. Herein, an injectable sodium alginate hydrogel membrane doped with bismuth oxychloride (BiOCl) and cubic cuprous oxide (CuO) nanoparticles was designed to simultaneously achieve local tooth whitening and biofilm removal through a photodynamic dental therapy process. This fast cross-linked hydrogel could form a biofilm removal coating on the target tooth surface precisely. Afterward, reactive oxygen species was effectively released on demand under green light, which could not only eradicate the biofilm but also whiten the tooth non-destructively in a facile manner without significant damage to both the enamel and biological cells. After the usage, the removal of this hydrogel can also enhance the effect of biofilm destruction and caries prevention.
生物膜驱动的龋齿和牙齿变色是口腔保健中的两个主要问题。目前的方法存在生物膜靶向性不足和釉质不可逆损伤的缺点。本研究设计了一种可注射的海藻酸钠水凝胶膜，其中掺杂了 BiOCl 和立方氧化亚铜 (CuO) 纳米粒子，通过光动力牙科治疗过程，同时实现局部牙齿美白和生物膜去除。这种快速交联的水凝胶可以精确地在目标牙齿表面形成生物膜去除涂层。随后，在绿光下按需有效释放活性氧，不仅可以消除生物膜，而且可以无创地美白牙齿，对釉质和生物细胞没有明显的损伤。使用后，这种水凝胶的去除也可以增强生物膜破坏和龋齿预防的效果。
